Matsuoka T
J Am Vet Med Assoc. 1976 Nov 15;169(10):1098-100.
Gelded horses of mixed breeding, ranging in weight between 360 and 455 kg, were fed pellets that contained monensin at concentrations of 279, 124, 31, and 0 ppm. Of 2 horses fed 279 ppm (253 g/T), both died. Of 3 horses fed 125 ppm (113 g/T), 1 died; feed intake was reduced in the 2 survivors. Of 3 horses fed 31 ppm (28 g/T), 1 had a transitory reduction in feed intake and the other 2 remained clinically normal. The 2 horses fed 0 ppm remained clinically normal. Monensin was also given to horses by gavage, at dosages of 1, 2, 3, 4, or 20 mg/kg of body weight. The LD50 was estimated to be between 2 and 3 mg/kg of body weight. The signs of toxicosis were partial to complete anorexia, ataxia, and intermittent profuse sweating.
体重在360至455千克之间的混种去势马，被喂食了含有浓度分别为279、124、31和0 ppm莫能菌素的颗粒饲料。喂食279 ppm（253克/吨）的2匹马均死亡。喂食125 ppm（113克/吨）的3匹马中，1匹死亡；另外2匹幸存者的采食量减少。喂食31 ppm（28克/吨）的3匹马中，1匹采食量暂时减少，另外2匹临床状况正常。喂食0 ppm的2匹马临床状况正常。莫能菌素也通过灌胃给予马匹，剂量为1、2、3、4或20毫克/千克体重。估计半数致死量为2至3毫克/千克体重。中毒症状为部分至完全厌食、共济失调和间歇性大量出汗。
