Grasland A, Le Maître F, Pouchot J, Hazera P, Bazin C, Vinceneux P
Service de médecine interne V, hôpital Louis-Mourier, Colombes.
Rev Med Interne. 1998 Feb;19(2):134-6. doi: 10.1016/s0248-8663(97)83425-x.
Hepatitis A and B vaccination are generally very well tolerated. However, exceptional cases of arthritis and systemic diseases have been reported after hepatitis B vaccination.
The authors report a case of adult Still's disease apparently triggered by hepatitis A and B vaccination. The patient was a 38-year-old woman who presented with fever, hepatitis, pneumonitis and neurologic symptoms, compatible with the diagnosis of adult Still's disease.
The authors discuss the rarity of systemic diseases triggered by such vaccination, the link between hepatitis B virus and some vasculitis, and the possibility for viral bacterial infections to trigger adult Still's disease.
甲型和乙型肝炎疫苗通常耐受性良好。然而，有报道称接种乙型肝炎疫苗后出现了关节炎和全身性疾病的特殊病例。
作者报告了一例显然由甲型和乙型肝炎疫苗引发的成人斯蒂尔病病例。患者为一名38岁女性，出现发热、肝炎、肺炎和神经系统症状，符合成人斯蒂尔病的诊断。
作者讨论了此类疫苗引发全身性疾病的罕见性、乙型肝炎病毒与某些血管炎之间的联系，以及病毒细菌感染引发成人斯蒂尔病的可能性。
