Furth P A
Department of Medicine, Institute of Human Virology, University of Maryland Medical School, Baltimore, USA.
Dev Biol Stand. 1998;94:281-7.
Transgenic mice have been used to study the process of Simian Virus 40 (SV40)-induced oncogenesis in a broad range of tissues including mammary gland, salivary gland, pancreas, prostate, liver, lung, kidney, intestine, brain, choroid plexus, lens of the eye, bone, smooth muscle and cartilage. The focus of these studies rests primarily on the action of the major transforming viral oncoprotein, the large T antigen (TAg). In most transgenic studies, the DNA coding sequence of the SV40 TAg is placed under the control of a tissue specific promoter which is responsible for directing TAg expression to the selected organ. This review focuses on the process of viral oncogenesis in the mammary and salivary glands. The role of TAg in the induction of apoptosis in the mammary gland, and the time-dependency of TAg induced hyperplastic changes in the salivary gland, are emphasized.
转基因小鼠已被用于研究猿猴病毒40（SV40）诱导的肿瘤发生过程，涉及多种组织，包括乳腺、唾液腺、胰腺、前列腺、肝脏、肺、肾脏、肠道、大脑、脉络丛、眼球晶状体、骨骼、平滑肌和软骨。这些研究的重点主要在于主要的转化病毒癌蛋白——大T抗原（TAg）的作用。在大多数转基因研究中，SV40 TAg的DNA编码序列置于组织特异性启动子的控制之下，该启动子负责将TAg表达导向选定的器官。本综述聚焦于乳腺和唾液腺中的病毒肿瘤发生过程。重点强调了TAg在乳腺细胞凋亡诱导中的作用，以及TAg诱导唾液腺增生性变化的时间依赖性。
