Pettersson A, Hedner T, Milsom I
Department of Clinical Pharmacology, Sahlgrenska University Hospital, Göteborg, Sweden.
Acta Obstet Gynecol Scand. 1998 Sep;77(8):808-13.
To study endogenous nitric oxide (NO) synthesis inhibitors in preeclampsia by measuring asymmetric dimethyl arginine (ADMA) and arginine.
Blood samples for measurement of plasma concentrations of ADMA and arginine were obtained antepartum (range 32-39 weeks gestation), 3-5 days postpartum and 3 months postpartum from 12 pregnant women with severe preeclampsia and from a normotensive pregnant control group (n=12).
During the third trimester, plasma ADMA was elevated (p<0.05) in the preeclampsia patients (0.55+/-0.02 micromol/l) compared to the normotensive pregnant controls (0.36+/-0.01 micromol/l). Since plasma arginine levels did not differ between preeclamptic and normotensive control women (80.7+/-5.8 micromol/l) and 74.5+/-3.8 micromol/l respectively), the plasma arginine/ADMA ratio was lower (p<0.05) in the preeclamptic group (145.6+/-10.5) compared to the normotensive controls (211.0+/-14.3). Three days post partum there was an increase (p<0.05) in plasma ADMA in both the preeclamptic (0.67+/-0.03 micromol/l) and the normotensive control group (0.64+/-0.03 micromol/l). This was accompanied by a rise (p<0.05) in plasma arginine levels in both the preeclamptic patients (112.9+/-10.5 micromol/l) and the normotensive control group (121.7+/-9.6 micromol/l). At this time point there was no difference in plasma arginine/ADMA ratio between the groups. Three months postpartum, plasma ADMA levels were slightly lower in both groups compared to the postpartum values (preeclampsia: 0.56+/-0.03 micromol/l, normotensive pregnant control: 0.52+/-0.03 micromol/l).
Elevated circulating ADMA concentrations in combination with low plasma arginine levels may be of pathophysiological importance in pregnancies complicated with preeclampsia.
通过测量不对称二甲基精氨酸（ADMA）和精氨酸，研究子痫前期患者体内内源性一氧化氮（NO）合成抑制剂。
采集12例重度子痫前期孕妇及12例血压正常的孕妇对照组（n = 12）产前（妊娠32 - 39周）、产后3 - 5天及产后3个月的血样，测定血浆中ADMA和精氨酸的浓度。
妊娠晚期，子痫前期患者血浆ADMA水平（0.55±0.02 μmol/l）高于血压正常的孕妇对照组（0.36±0.01 μmol/l）（p<0.05）。由于子痫前期患者与血压正常的孕妇对照组血浆精氨酸水平无差异（分别为80.7±5.8 μmol/l和74.5±3.8 μmol/l），子痫前期组血浆精氨酸/ADMA比值（145.6±10.5）低于血压正常的对照组（211.0±14.3）（p<0.05）。产后3天，子痫前期组（0.67±0.03 μmol/l）和血压正常的对照组（0.64±0.03 μmol/l）血浆ADMA水平均升高（p<0.05）。同时，子痫前期患者（112.9±10. "5 μmol/l）和血压正常的对照组（121.7±9.6 μmol/l）血浆精氨酸水平也升高（p<0.05）。此时两组血浆精氨酸/ADMA比值无差异。产后3个月，两组血浆ADMA水平均略低于产后值（子痫前期组：0.56±0.03 μmol/l，血压正常的孕妇对照组：0.52±0.03 μmol/l）。
循环中ADMA浓度升高及血浆精氨酸水平降低可能在子痫前期妊娠中具有病理生理学意义。
