异常毕赤酵母杀伤毒素对白色念珠菌的作用。

Effect of Pichia anomala killer toxin on Candida albicans.

作者信息

Mathews H L, Conti S, Witek-Janusek L, Polonelli L

机构信息

Department of Microbiology and Immunology, Loyola University of Chicago, Maywood, IL,

出版信息

Med Mycol. 1998 Aug;36(4):199-204.

PMID:9776835

Abstract

The effect of a Pichia anomala killer toxin upon a Candida albicans-sensitive strain was studied. Yeast and hyphae, after treatment with the toxin, were less capable of uptaking either [3H]-uridine or [35S]-methionine. In addition, the hyphal form of the fungus appeared to be less capable of DNA synthesis after toxin treatment. No effect of the killer toxin was shown upon a natural resistant mutant of the source strain. These data suggest that, similar to other killer yeast toxins, the toxin of P. anomala can produce a number of quantifiable effects upon sensitive C. albicans cells.

摘要

研究了异常毕赤酵母杀伤毒素对白色念珠菌敏感菌株的作用。用该毒素处理后，酵母和菌丝摄取[3H] - 尿苷或[35S] - 甲硫氨酸的能力降低。此外，毒素处理后真菌的菌丝形态似乎DNA合成能力降低。杀伤毒素对源菌株的天然抗性突变体没有作用。这些数据表明，与其他杀伤酵母毒素类似，异常毕赤酵母毒素可对敏感的白色念珠菌细胞产生许多可量化的影响。