假孕期间兔黄体对前列腺素F2α类似物阿法前列醇的反应性变化。

Changes in refractoriness of rabbit corpora lutea to a prostaglandin F2 alpha analogue, alfaprostol, during pseudopregnancy.

作者信息

Boiti C, Canali C, Zerani M, Gobbetti A

机构信息

Istituto di Fisiologia veterinaria, Università di Perugia, Italia.

出版信息

Prostaglandins Other Lipid Mediat. 1998 Jul;56(4):255-64. doi: 10.1016/s0090-6980(98)00053-7.

DOI:10.1016/s0090-6980(98)00053-7

PMID:9777657

Abstract

The responsiveness of rabbit corpus luteum to 200 micrograms of the prostaglandin F2 alpha (PGF2 alpha) analogue, alfaprostol, between Days 3 and 9 of pseudopregnancy was assessed by evaluating the decline in plasma progesterone after treatment with PGF2 alpha in 81 New Zealand White (NZW) rabbits. On Days 3-5, functional luteolysis was not observed. On Days 6, 7, and 8 of pseudopregnancy, the number of rabbits responsive to PGF2 alpha, rose from 38% to 71% and 83%, respectively. In the other cases, the effect of the PGF2 alpha analogue was transient as CL recovered in the following 2 or 3 days. By contrast, on Day 9 luteolysis was effective and persistent in all the animals. In rabbits treated on Day 9, progesterone decreased gradually from 10.6 +/- 0.7 within the first 6 h, but fell to 3.6 +/- 1.5 ng/mL (p < 0.01) 12 h after PGF2 alpha and to 0.2 +/- 0.1 ng/mL (p < 0.01) 24 h later.

摘要

通过评估81只新西兰白兔（NZW）经前列腺素F2α（PGF2α）类似物alfaprostol处理后血浆孕酮的下降情况，来评估假孕第3天至第9天兔黄体对200微克PGF2α的反应性。在第3 - 5天，未观察到功能性黄体溶解。在假孕的第6、7和8天，对PGF2α有反应的兔子数量分别从38%升至71%和83%。在其他情况下，PGF2α类似物的作用是短暂的，因为黄体在接下来的2或3天内恢复。相比之下，在第9天，所有动物的黄体溶解都是有效且持续的。在第9天接受治疗的兔子中，孕酮在最初6小时内从10.6±0.7逐渐下降，但在PGF2α处理12小时后降至3.6±1.5纳克/毫升（p<0.01），24小时后降至0.2±0.1纳克/毫升（p<0.01）。