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假孕兔黄体中 kisspeptin/kisspeptin 受体系统：存在与功能。

Kisspeptin/kisspeptin receptor system in pseudopregnant rabbit corpora lutea: presence and function.

机构信息

Dipartimento di Medicina veterinaria, Università di Perugia, via San Costanzo 4, Perugia, IT, 06126, Italy.

Scuola di Bioscienze e Medicina veterinaria, Università di Camerino, via Circonvallazione 93, Matelica, IT, 62024, Italy.

出版信息

Sci Rep. 2019 Mar 25;9(1):5044. doi: 10.1038/s41598-019-41623-1.

DOI:10.1038/s41598-019-41623-1
PMID:30911071
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6433948/
Abstract

Kisspeptin (KiSS) and its related receptors (KiSS1R) have a critical role in the reproduction of mammals. The KiSS/KiSS1R system is expressed in numerous reproductive organs including the ovary. Here, we studied the expression of the KiSS/KiSS1R system and its functional role in rabbit corpora lutea (CL) at days 4 (early-), 9 (mid-), and 13 (late-stage) of pseudopregnancy. In vitro progesterone, prostaglandin (PG) F2α (PGF2α) and E2 (PGE2) productions and prostaglandin-endoperoxide synthase 1 (PTGS1) and 2 (PTGS2) activities were evaluated. Immune reactivity (IR) for KiSS and KiSS1R were detected in luteal cells at nuclear and cytoplasmic level at all luteal stage for KiSS and only at early- and mid-stage for KiSS1R; IR decreased from early- to later stages of pseudopregnancy. The KiSS-10 augmented progesterone and PGE2 and diminished PGF2α secretions by early- and mid-CL; KiSS-10 reduced PTGS2 activity at early- and mid-stages, but did not affect PTGS1 at any luteal stages. The antagonist KiSS-234 counteracted all KiSS-10 effects. This study shows that the KiSS/KiSS1R system is expressed in CL of pseudopregnant rabbits and exerts a luteotropic action by down-regulating PTGS2, which decreases PGF2α and increases PGE2 and progesterone.

摘要

kisspeptin（KiSS）及其相关受体（KiSS1R）在哺乳动物的生殖中起着关键作用。KiSS/KiSS1R 系统在许多生殖器官中表达，包括卵巢。在这里，我们研究了 kisspeptin（KiSS）/kiss1r 系统在兔假孕第 4 天（早期）、9 天（中期）和 13 天（晚期）黄体中的表达及其功能作用。评估了黄体体外孕激素、前列腺素（PG）F2α（PGF2α）和 E2（PGE2）的产生以及前列腺素内过氧化物合酶 1（PTGS1）和 2（PTGS2）的活性。在黄体的所有阶段，KiSS 和 KiSS1R 的免疫反应（IR）都在核和细胞质水平上检测到；而 KiSS1R 的免疫反应仅在早期和中期黄体中检测到；IR 从早期到假孕晚期逐渐降低。KiSS-10 在早期和中期黄体中增加了孕激素和 PGE2 的分泌，并减少了 PGF2α 的分泌；KiSS-10 在早期和中期阶段降低了 PTGS2 的活性，但在任何黄体阶段均不影响 PTGS1。KiSS-234 拮抗剂拮抗了 KiSS-10 的所有作用。这项研究表明，KiSS/KiSS1R 系统在假孕兔黄体中表达，并通过下调 PTGS2 发挥黄体作用，从而减少 PGF2α，增加 PGE2 和孕激素。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/47da/6433948/914679504556/41598_2019_41623_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/47da/6433948/d0f20c2aba83/41598_2019_41623_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/47da/6433948/f3724b015f3e/41598_2019_41623_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/47da/6433948/9a5d5697599f/41598_2019_41623_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/47da/6433948/0bf67a26551e/41598_2019_41623_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/47da/6433948/914679504556/41598_2019_41623_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/47da/6433948/d0f20c2aba83/41598_2019_41623_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/47da/6433948/f3724b015f3e/41598_2019_41623_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/47da/6433948/9a5d5697599f/41598_2019_41623_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/47da/6433948/0bf67a26551e/41598_2019_41623_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/47da/6433948/914679504556/41598_2019_41623_Fig5_HTML.jpg

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