Mellemgaard A, From G, Jørgensen T, Johansen C, Olsen J H, Perrild H
Danish Cancer Society, Division of Cancer Epidemiology, Strandboulevarden.
Thyroid. 1998 Sep;8(9):751-4. doi: 10.1089/thy.1998.8.751.
The risk of cancer was examined in a cohort of 57,326 individuals who were discharged from a Danish hospital with a diagnosis of myxedema, thyrotoxicosis, or goiter. Although the general risk of cancer was only slightly increased, the risk of several sites was significantly above expected. The risk of thyroid cancer especially, was increased with standardized incidence ratios among women of 2.1 (myxedema), 2.5 (thyrotoxicosis), and 6.6 (nontoxic goiter). The increase in risk was present even many years after discharge, indicating that surveillance was not the only explanation. Furthermore, an increased risk was noted for cancer of the kidney in women discharged with myxedema (standardized incidence ratios [SIR] = 1.8) and thyrotoxicosis (SIR = 1.3), for cancer of the bladder in women discharged with myxedema (SIR = 1.5) and nontoxic goiter (SIR = 1.3), and for cancer of the hematopoetic system in women discharged with myxedema (SIR = 1.4) and nontoxic goiter (SIR = 1.4). The findings indicate that thyroid disorders may be related to cancer risk of several specific sites other than the thyroid.
在一个队列研究中，对57326名从丹麦医院出院、诊断为黏液性水肿、甲状腺毒症或甲状腺肿的个体进行了癌症风险检查。尽管总体癌症风险仅略有增加，但几个部位的风险显著高于预期。特别是甲状腺癌的风险增加，女性的标准化发病比分别为2.1（黏液性水肿）、2.5（甲状腺毒症）和6.6（非毒性甲状腺肿）。即使在出院多年后风险仍存在增加，这表明监测不是唯一的解释。此外，黏液性水肿（标准化发病比[SIR]=1.8）和甲状腺毒症（SIR=1.3）出院的女性患肾癌的风险增加，黏液性水肿（SIR=1.5）和非毒性甲状腺肿（SIR=1.3）出院的女性患膀胱癌的风险增加，黏液性水肿（SIR=1.4）和非毒性甲状腺肿（SIR=1.4）出院的女性患造血系统癌症的风险增加。这些发现表明，甲状腺疾病可能与甲状腺以外的几个特定部位的癌症风险有关。
