Dijkstra J B, Van Boxtel M P, Houx P J, Jolles J
Brain and Behavior Research Institute, Maastricht University, The Netherlands.
J Am Geriatr Soc. 1998 Oct;46(10):1258-65. doi: 10.1111/j.1532-5415.1998.tb04542.x.
To evaluate the factor 'operation under general anesthesia' as a possible risk factor for age-related cognitive decline.
A retrospective, population-based, cross-sectional study.
Maastricht Aging Study (MAAS), Maastricht, The Netherlands.
1257 normal healthy subjects aged 24 to 86 years. Of the 1257 healthy subjects, 946 subjects appeared to have undergone at least one operation under general anesthesia.
The history of an operation under general anesthesia, number of operations, duration of anesthesia, cognitive performance, subjective health, and subjective memory were measured.
A history of an operation under general anesthesia, the number of operations, and the total duration of anesthesia significantly contributed to the number of subjective health-related complaints but did not predict cognitive performance or memory complaints. Subjects with a history of an operation under general anesthesia felt less healthy than subjects who had never undergone an operation under general anesthesia. No interactions with age were found.
The present study found no support for the notion that a history of an operation under general anesthesia is a determinant or risk factor for accelerated age-related cognitive decline.
评估“全身麻醉下手术”这一因素作为年龄相关性认知衰退潜在风险因素的情况。
一项基于人群的回顾性横断面研究。
荷兰马斯特里赫特的马斯特里赫特衰老研究（MAAS）。
1257名年龄在24至86岁之间的正常健康受试者。在这1257名健康受试者中，946名似乎至少接受过一次全身麻醉下的手术。
测量全身麻醉下手术史、手术次数、麻醉持续时间、认知表现、主观健康状况和主观记忆情况。
全身麻醉下手术史、手术次数和麻醉总时长对与主观健康相关的投诉数量有显著影响，但不能预测认知表现或记忆方面的投诉。有全身麻醉下手术史的受试者感觉不如从未接受过全身麻醉下手术的受试者健康。未发现与年龄的相互作用。
本研究未支持全身麻醉下手术史是加速年龄相关性认知衰退的决定因素或风险因素这一观点。
