Doraiswamy P M, Steffens D C
Department of Psychiatry and Behavioral Sciences and the Center for the Study of Aging and Human Development, Duke University Medical Center, Durham, North Carolina 27710, USA.
J Am Geriatr Soc. 1998 Oct;46(10):1322-4. doi: 10.1111/j.1532-5415.1998.tb04556.x.
The practical pharmacological approaches currently available to palliate the cognitive and functional losses in early Alzheimer's disease (AD) include cholinesterase inhibitors (ChEI), antioxidants (e.g., vitamin E), anti-inflammatory agents, estrogen, seligiline, vasoactive agents, and ginkgo biloba. Reviewing available data on these therapies and using models from medical illnesses such as cancer and hypertension, we highlight the urgent need for evaluating combination therapies in early AD.
目前可用于缓解早期阿尔茨海默病（AD）认知和功能丧失的实用药理学方法包括胆碱酯酶抑制剂（ChEI）、抗氧化剂（如维生素E）、抗炎药、雌激素、司来吉兰、血管活性药物和银杏叶。回顾这些疗法的现有数据，并借鉴癌症和高血压等医学疾病的模型，我们强调了在早期AD中评估联合疗法的迫切需求。
