Hutchison W D, Allan R J, Opitz H, Levy R, Dostrovsky J O, Lang A E, Lozano A M
Department of Surgery, Toronto Hospital (Western Division), Ontario, Canada.
Ann Neurol. 1998 Oct;44(4):622-8. doi: 10.1002/ana.410440407.
Microelectrode recording methods for stereotactic localization of the subthalamic nucleus (STN) and surrounding structures are described. These methods accurately define targets for chronic deep brain stimulation in the treatment of Parkinson's disease. Mean firing rates and a burst index were determined for all recorded neurons, and responses to active and passive limb and orofacial movements were tested. STN neurons had a mean firing rate of 37+/-17 Hz (n = 248) and an irregular firing pattern (median burst index, 3.3). Movement-related activity and tremor cells were identified in the STN. Ventral to the STN, substantia nigra pars reticulata neurons had a mean rate of 71+/-23 Hz (n = 56) and a more regular firing pattern (median burst index, 1.7). Short trains (1-2 seconds) of electrical microstimulation of STN could produce tremor arrest but were not found to be useful for localization. Compared with data from normal monkeys our findings suggest that STN neuronal activity is elevated in Parkinson's disease.
描述了用于丘脑底核（STN）及周围结构立体定向定位的微电极记录方法。这些方法精确地确定了用于治疗帕金森病的慢性深部脑刺激的靶点。测定了所有记录神经元的平均放电率和爆发指数，并测试了对主动和被动肢体及口面部运动的反应。STN神经元的平均放电率为37±17Hz（n = 248），放电模式不规则（中位爆发指数为3.3）。在STN中识别出了与运动相关的活动和震颤细胞。在STN腹侧，黑质网状部神经元的平均放电率为71±23Hz（n = 56），放电模式更规则（中位爆发指数为1.7）。对STN进行短时间（1 - 2秒）的电微刺激可使震颤停止，但未发现其对定位有用。与正常猴子的数据相比，我们的研究结果表明帕金森病中STN神经元活动增强。
