Nagano S, Takaki K, Umeno M, Okamoto K, Takeda T, Shirakusa T
Department of Internal Medicine, SAWARA Hospital, Fukuoka.
Fukuoka Igaku Zasshi. 1998 Aug;89(8):249-54.
A 56-year-old female was admitted on November 1995 to our hospital because of the abnormal shadow on her chest X-ray. Although the chest X ray film revealed diffuse reticulonodular shadows in the bilateral lung fields and right hilar lymphadenopathy, she had not any complaints. Furthermore, mediastinal lymphadenopathy and polyclonal hypergammaglobulinemia were noted. For a further examination, transcutaneous thoracoscopic lung biopsy was performed on August 1996. The lung specimens showed a interstitial infiltration of small lymphocytes exclusively around bronchioles. And the diagnosis of lymphocytic interstitial pneumonia (LIP) was made. She had been suffered from bronchial asthma for 27 years. This is the first report of LIP accompanied with bronchial asthma. Its relationship between LIP and bronchial asthma remains unclear. In the 2 years of follow-up, she remained asymptomatic with unchanged chest radiogram. And her pulmonary function was preserved for the 2 years. But lymphocytic interstitial pneumonia may induce malignant lymphoproliferative disease potentially, we should carefully follow up.
一名56岁女性于1995年11月因胸部X光片出现异常阴影而入住我院。尽管胸部X光片显示双侧肺野有弥漫性网状结节阴影以及右肺门淋巴结肿大，但她并无任何不适主诉。此外，还发现有纵隔淋巴结肿大及多克隆高球蛋白血症。为进一步检查，于1996年8月进行了经皮胸腔镜肺活检。肺标本显示仅在细支气管周围有小淋巴细胞的间质浸润。于是诊断为淋巴细胞间质性肺炎（LIP）。她患支气管哮喘已有27年。这是首例伴有支气管哮喘的LIP报告。LIP与支气管哮喘之间的关系仍不清楚。在2年的随访中，她一直无症状，胸部X光片无变化。并且其肺功能在这2年中得以保留。但淋巴细胞间质性肺炎可能潜在地诱发恶性淋巴增殖性疾病，我们应仔细随访。
