Day S E, Gedeit R G
Division of Pediatric Critical Care, Medical College of Wisconsin, Milwaukee, USA.
Clin Perinatol. 1998 Sep;25(3):711-22.
For decades, the fluid-filled lung has been a valuable research model for understanding normal and abnormal pulmonary physiology. It has lagged behind, however, as a useful therapeutic tool. Recently, the potential applications of perflubron's physicochemical and biologic properties have been realized. In animal models of several types of hypoxic respiratory failure, perflubron's efficacy in improving gas exchange and compliance has been demonstrated. Preliminary clinical studies of PLV in neonates who have RDS and CDH, and in children and adults who have ARDS have shown promise. Pivotal prospective, controlled studies have yet to be completed.
几十年来，充满液体的肺一直是理解正常和异常肺生理学的宝贵研究模型。然而，作为一种有用的治疗工具，它却落后了。最近，全氟溴烷的物理化学和生物学特性的潜在应用已得到认识。在几种类型的低氧性呼吸衰竭动物模型中，全氟溴烷在改善气体交换和顺应性方面的功效已得到证实。对患有呼吸窘迫综合征和先天性膈疝的新生儿以及患有急性呼吸窘迫综合征的儿童和成人进行肺液体通气的初步临床研究已显示出前景。关键性的前瞻性对照研究尚未完成。
