Hirschl R B, Pranikoff T, Gauger P, Schreiner R J, Dechert R, Bartlett R H
Department of Surgery, University of Michigan, Ann Arbor, USA.
Lancet. 1995 Nov 4;346(8984):1201-2. doi: 10.1016/s0140-6736(95)92903-7.
We evaluated the safety and efficacy of partial liquid ventilation in a series of 19 adults, children, and neonates who were in respiratory failure and on extracorporeal life support. During partial liquid ventilation, the alveolar-arterial oxygen difference decreased from 590 (SE 25) to 471 (42) mm Hg (p = 0.0002) and static pulmonary compliance increased from 0.18 (0.04) to 0.29 (0.04) mL cm H2O-1 kg-1 (p = 0.0002). 11 patients (58%) survived. These preliminary data suggest that partial liquid ventilation can be safely used in patients with severe respiratory failure and may improve lung function.
我们评估了部分液体通气对19例呼吸衰竭且接受体外生命支持的成人、儿童和新生儿的安全性和有效性。在部分液体通气期间，肺泡-动脉氧分压差从590（标准误25）降至471（42）mmHg（p = 0.0002），静态肺顺应性从0.18（0.04）增至0.29（0.04）mL cm H₂O⁻¹ kg⁻¹（p = 0.0002）。11例患者（58%）存活。这些初步数据表明，部分液体通气可安全用于严重呼吸衰竭患者，并可能改善肺功能。
