Millemann Y
Laboratoire d'écopathologie microbienne, centre de recherche Inra de Tours, Nouzilly, France.
Vet Res. 1998 Sep-Oct;29(5):385-407.
Salmonellae are potentially pathogenic for humans as well as for numerous animal species. They possess numerous virulence factors, which allow them to adapt to various environmental conditions and to host response at each step of the pathogenic process. Key-steps such as the invasion of epithelial cells or survival within macrophages have been extensively studied. These studies have led to the discovery of an original protein secretion system and have demonstrated the existence of pathogenicity islands. This considerable progress is due to the development of numerous in vitro and in vivo models and of new identification strategies for the implicated genes. Recently, many original and elegant strategies have been recently proposed.
沙门氏菌对人类以及众多动物物种都具有潜在致病性。它们拥有众多毒力因子，这使它们能够在致病过程的每个阶段适应各种环境条件并应对宿主反应。诸如上皮细胞侵袭或巨噬细胞内存活等关键步骤已得到广泛研究。这些研究促成了一种原始蛋白质分泌系统的发现，并证明了致病岛的存在。这一重大进展归功于众多体外和体内模型以及相关基因新鉴定策略的发展。最近，人们提出了许多新颖而巧妙的策略。
