Mielke R, Zerres K, Uhlhaas S, Kessler J, Heiss W D
Max-Planck-Institut für Neurologische Forschung und Universitätsklinik für Neurologie, Köln, Germany.
Neurosci Lett. 1998 Sep 18;254(1):49-52. doi: 10.1016/s0304-3940(98)00673-9.
In 49 patients with the clinical diagnosis of probable Alzheimer's disease (AD) apoE genotyping as well as regional cerebral glucose metabolism (rCMRGI) using positron emission tomography (PET) of [18F]2-fluoro-2-deoxy-D-glucose (FDG) were studied. The metabolic pattern was condensed to a ratio by dividing the rCMRGI of typically affected regions (temporo-parietal and frontal association cortex) by the rCMRGI of the least affected regions (primary cortical areas, basal ganglia, cerebellum and brainstem). Epsilon4-heterozygotes and epsilon4-homozygotes were grouped together, and also those lacking the epsilon4-allele (non-epsilon4). For the metabolic pattern we found a significant correlation to severity of dementia in both groups (epsilon4: r = 0.49, P = 0.05; non-epsilon4: r = 0.59, P = 0.006). On ANCOVA severity of dementia and epsilon4 status were independent predictors of the cerebral metabolic pattern (P = 0.01). These differences may be attributed to epsilon4 dependent histopathologic changes.
对49例临床诊断为可能的阿尔茨海默病（AD）的患者进行了载脂蛋白E（apoE）基因分型以及使用[18F]2-氟-2-脱氧-D-葡萄糖（FDG）正电子发射断层扫描（PET）测定局部脑葡萄糖代谢（rCMRGI）的研究。通过将典型受累区域（颞顶叶和额叶联合皮质）的rCMRGI除以受累最少区域（初级皮质区、基底神经节、小脑和脑干）的rCMRGI，将代谢模式浓缩为一个比值。ε4杂合子和ε4纯合子归为一组，缺乏ε4等位基因的患者（非ε4）也归为一组。对于代谢模式，我们发现两组中代谢模式与痴呆严重程度均存在显著相关性（ε4组：r = 0.49，P = 0.05；非ε4组：r = 0.59，P = 0.006）。在协方差分析中，痴呆严重程度和ε4状态是脑代谢模式的独立预测因素（P = 0.01）。这些差异可能归因于ε4依赖性组织病理学变化。
