Hirono N, Mori E, Yasuda M, Ishii K, Ikejiri Y, Imamura T, Shimomura T, Hashimoto M, Yamashita H, Sasaki M
Department of Clinical Neurosciences, Hyogo Institute for Aging Brain and Cognitive Disorders, Himeji, Japan.
Alzheimer Dis Assoc Disord. 1998 Dec;12(4):362-7. doi: 10.1097/00002093-199812000-00018.
Parietal cerebral glucose metabolism is reduced before substantial impairments appeared in subjects carrying the apolipoprotein E (APOE) epsilon4 allele, but the effect of the APOE epsilon4 allele on cerebral metabolism in Alzheimer disease (AD) is still undetermined. To investigate the effect of the APOE epsilon4 allele on cerebral metabolism in AD, we examined regional cerebral glucose metabolism in 83 patients with AD by using 18F-fluorodeoxyglucose and positron emission tomography. Cerebral glucose metabolism in the fronto-parieto-temporal association and limbic cortices was significantly decreased in the AD patients compared with 26 age- and sex-matched normal controls. Regional cerebral glucose metabolic rate was not correlated significantly with the number of APOE epsilon4 alleles in any region, which was consistent even after controlling the effects of age, sex, and severity of dementia, and in a subgroup analysis of those aged between 60 and 75. These results supported the view that the APOE epsilon4 allele is not associated with specific deficits in brain metabolism in AD despite evidence of preclinical alterations.
在携带载脂蛋白E（APOE）ε4等位基因的受试者出现明显损伤之前，顶叶脑葡萄糖代谢就已降低，但APOE ε4等位基因对阿尔茨海默病（AD）脑代谢的影响仍未确定。为了研究APOE ε4等位基因对AD脑代谢的影响，我们使用18F-氟脱氧葡萄糖和正电子发射断层扫描技术检查了83例AD患者的局部脑葡萄糖代谢。与26名年龄和性别匹配的正常对照相比，AD患者额颞顶叶联合区和边缘皮质的脑葡萄糖代谢显著降低。在任何区域，局部脑葡萄糖代谢率均与APOE ε4等位基因的数量无显著相关性，即使在控制了年龄、性别和痴呆严重程度的影响后，以及在60至75岁亚组分析中也是如此。这些结果支持了这样一种观点，即尽管有临床前改变的证据，但APOE ε4等位基因与AD患者脑代谢的特定缺陷无关。
