Hara T, Inami M, Hara T
Hara Eye Hospital, Utsunomiya, Japan.
Am J Ophthalmol. 1998 Oct;126(4):560-4. doi: 10.1016/s0002-9394(98)00112-3.
To report the efficacy and safety of fluorescein angiography after oral administration of fluorescein solution in a large number of patients during a period of 8 years.
A total of 1,787 patients (2,625 eyes) underwent fluorescein angiography after oral administration of sodium fluorescein at Hara Eye Hospital, Utsunomiya, Japan, between January 1989 and March 1997. The ingestible solution was 10 ml of 10% sodium fluorescein, the same material generally used for injection in conventional fluorescein angiography. Retinal photography began 15 minutes after ingestion and continued for 1 hour. The camera and the photography and film processing techniques were the same as those used for conventional fluorescein angiography using injected sodium fluorescein.
In 2,554 (97.3%) of 2,625 eyes, photographs adequate for clinical use were obtained. In 1,787 patients, no anaphylactic or other severe adverse effects were observed, and only 31 patients (1.7%) experienced minimal itching, discomfort, or nausea after oral sodium fluorescein intake. For conditions such as central serous chorioretinopathy, retinal vein occlusion, diabetic retinopathy, and cystoid macular edema, sufficient information for clinical use was obtained.
Fluorescein angiography using orally administered sodium fluorescein is generally effective and safe in standard clinical practice.
报告在8年期间对大量患者口服荧光素溶液后进行荧光素血管造影的有效性和安全性。
1989年1月至1997年3月期间，日本宇都宫原眼科医院对1787例患者（2625只眼）口服荧光素钠后进行了荧光素血管造影。可口服溶液为10ml 10%的荧光素钠，与传统荧光素血管造影中通常用于注射的材料相同。摄入后15分钟开始进行视网膜摄影，并持续1小时。相机以及摄影和胶片冲洗技术与使用注射荧光素钠的传统荧光素血管造影相同。
2625只眼中有2554只眼（97.3%）获得了适用于临床的照片。在1787例患者中，未观察到过敏或其他严重不良反应，仅31例患者（1.7%）在口服荧光素钠后出现轻微瘙痒、不适或恶心。对于中心性浆液性脉络膜视网膜病变、视网膜静脉阻塞、糖尿病视网膜病变和黄斑囊样水肿等病症，获得了足够的临床应用信息。
在标准临床实践中，口服荧光素钠进行荧光素血管造影总体上是有效且安全的。
