Kawahara H, Sakaguchi N, Iikura Y, Saito H, Akasawa A
Department of Pediatrics, Showa Medical School.
Arerugi. 1998 Jul;47(7):679-86.
Thirty asthmatic children were examined allergic reaction against egg white, gelatin and vaccine solution before and after vaccination using skin prick test. We also measured the levels of specific IgE and IgG antibody against gelatin. The changes in clinical symptoms before and after vaccination were investigated in 25 asthmatic children by evaluating symptom and treatment score. The results were as follows; 1. In one subject who had delayed type of skin reaction to gelatin, the adverse reaction was also recognized at the skin site around 24 hrs after vaccination. In this subject, the levels of serum specific IgE and IgG to gelatin became positive after 5 months. 2. Specific IgE antibodies to gelatin were not detected in all subjects before and after vaccination. 3. The mean values of asthma symptom score before and after vaccination were 3.3 +/- 4.2 and 1.5 +/- 3.3 respectively. Those of treatment score before and after vaccination were 75.6 +/- 35.2 and 76.0 +/- 35.0 respectively. These results suggest that skin testing with gelatin and vaccine solution is useful as a screening method for predicting adverse reactions in asthmatic children and that influenza vaccination can be performed safely in skin test negative children.
30名哮喘儿童在接种疫苗前后，通过皮肤点刺试验检测了对蛋清、明胶和疫苗溶液的过敏反应。我们还测量了针对明胶的特异性IgE和IgG抗体水平。通过评估症状和治疗评分，对25名哮喘儿童接种疫苗前后的临床症状变化进行了调查。结果如下：1. 在一名对明胶有迟发型皮肤反应的受试者中，接种疫苗后约24小时在皮肤部位也出现了不良反应。在该受试者中，5个月后血清中针对明胶的特异性IgE和IgG水平呈阳性。2. 接种疫苗前后所有受试者均未检测到针对明胶的特异性IgE抗体。3. 接种疫苗前后哮喘症状评分的平均值分别为3.3±4.2和1.5±3.3。接种疫苗前后治疗评分的平均值分别为75.6±35.2和76.0±35.0。这些结果表明，用明胶和疫苗溶液进行皮肤试验作为预测哮喘儿童不良反应的筛查方法是有用的，并且在皮肤试验阴性的儿童中可以安全地进行流感疫苗接种。
