Aguayo A J, Charron L, Bray G M
J Neurocytol. 1976 Oct;5(8):565-73. doi: 10.1007/BF01175570.
In adult mice, most fibres in the cervical sympathetic trunk (CST) are unmyelinated whereas a large proportion of sural nerve fibres are myelinated. This study of nerve grafts in syngeneic mice was designed to determine if Schwann cells originating from the unmyelinated CST would produce myelin when in contact with regenerating axons of the sural nerve. Quantitative microscopy of triated thymidine-labelled CST segments grafted to unlabelled sural nerve stumps revealed that, one month after grafting, previously unmyelinated grafts contained many myelinated fibres. By phase and electron microscope radioautography, nearly 40% of the myelin-producing cells in the reinnervated graft were shown to have originated in the unmyelinated CST. These findings indicate that Schwann cells originating from unmyelinated fibres are able to differentiate into myelin producing cells.
在成年小鼠中，颈交感干（CST）的大多数纤维是无髓鞘的，而腓肠神经纤维的很大一部分是有髓鞘的。这项对同基因小鼠神经移植的研究旨在确定源自无髓鞘CST的雪旺细胞在与腓肠神经再生轴突接触时是否会产生髓鞘。对移植到未标记腓肠神经残端的经氚化胸腺嘧啶核苷标记的CST节段进行定量显微镜检查发现，移植后一个月，先前无髓鞘的移植物中含有许多有髓鞘纤维。通过相位和电子显微镜放射自显影术显示，在重新支配的移植物中，近40%产生髓鞘的细胞起源于无髓鞘的CST。这些发现表明，源自无髓鞘纤维的雪旺细胞能够分化为产生髓鞘的细胞。
