von Rückmann A, Schmidt K G, Fitzke F W, Bird A C, Jacobi K W
Univ.-Augenklinik, Giessen.
Klin Monbl Augenheilkd. 1998 Aug;213(2):81-6. doi: 10.1055/s-2008-1034951.
The lack of histopathological material has placed limitation on our knowledge on the composition of focal deposits in eyes with macular dystrophies, malattia leventinese, dominant drusen and age related macular degeneration. This study was designed to study the composition of focal deposits in these eyes by documenting fundus autofluorescence in vivo.
Fundus autofluorescence was documented in 343 eyes of 199 subjects with macular dystrophies, malattia leventinese, dominant drusen and age-related macular degeneration using a laser scanning ophthalmoscope (Zeiss, Oberkochen; excitation wavelength: 488 nm, barrier filter at 521 nm).
Autofluorescence of focal deposits was increased in eyes with macular dystrophies. In eyes with malattia leventinese and dominant drusen autofluorescence intensity of focal deposits showed a wide spectrum. In contrast, autofluorescence of age-related drusen was within normal limits. Background autofluorescence intensity was increased in eyes with macular dystrophies and within normal limits in eyes with malattia leventinese, dominant drusen and age-related drusen.
The technique of in-vivo recording of fundus autofluorescence allows the differential diagnosis between macular dystrophies/malattia leventinese, dominant drusen/age related drusen when otherwise not possible.
缺乏组织病理学材料限制了我们对患有黄斑营养不良、莱文廷斯病、显性玻璃膜疣和年龄相关性黄斑变性的眼睛中局灶性沉积物组成的了解。本研究旨在通过记录活体眼底自发荧光来研究这些眼睛中局灶性沉积物的组成。
使用激光扫描检眼镜（蔡司，奥伯科亨；激发波长：488nm，521nm的阻挡滤光片）对199名患有黄斑营养不良、莱文廷斯病、显性玻璃膜疣和年龄相关性黄斑变性的受试者的343只眼睛进行眼底自发荧光记录。
黄斑营养不良患者眼睛中局灶性沉积物的自发荧光增强。在患有莱文廷斯病和显性玻璃膜疣的眼睛中，局灶性沉积物的自发荧光强度呈现出广泛的范围。相比之下，年龄相关性玻璃膜疣的自发荧光在正常范围内。黄斑营养不良患者眼睛的背景自发荧光强度增加，而患有莱文廷斯病、显性玻璃膜疣和年龄相关性玻璃膜疣的眼睛的背景自发荧光强度在正常范围内。
活体记录眼底自发荧光的技术在其他方法不可行时，可用于黄斑营养不良/莱文廷斯病、显性玻璃膜疣/年龄相关性玻璃膜疣之间的鉴别诊断。
