Frank Y, Seiden J A, Napolitano B
Division of Pediatric Neurology, North Shore University Hospital, New York University School of Medicine, Manhasset 11030, USA.
Clin Electroencephalogr. 1998 Oct;29(4):188-93. doi: 10.1177/155005949802900412.
This study investigated age-related electrophysiological differences between children diagnosed with Learning Disabilities (LD), Attention Deficit Hyperactivity Disorder (ADHD), LD-ADHD and Conduct Disorder, using Event-Related Potentials recorded during a two-tone discrimination test. Although age-related (N1 and N2 amplitude), as well as diagnostic group-related (P3 latency and amplitude) ERP changes were found, there was no significant interaction between the diagnostic groups and age grouping. We conclude that: 1) Electrophysiological abnormalities in LD and ADHD do not significantly change with age during childhood. This study does not, therefore, support a hypothesis of age-related brain abnormalities in LD and ADHD. 2) Significant group differences for P3 latency and amplitude were found between normal children and the LD groups (LD and LD-ADHD), but not between normal children and those with ADHD alone, suggesting that main correlates of P3 abnormalities in these children are "processing" and not attentional problems.
本研究利用在双音辨别测试期间记录的事件相关电位，调查了被诊断为学习障碍（LD）、注意力缺陷多动障碍（ADHD）、LD-ADHD和品行障碍的儿童之间与年龄相关的电生理差异。尽管发现了与年龄相关的（N1和N2波幅）以及与诊断组相关的（P3潜伏期和波幅）ERP变化，但诊断组与年龄分组之间没有显著的交互作用。我们得出以下结论：1）LD和ADHD中的电生理异常在儿童期不会随年龄显著变化。因此，本研究不支持LD和ADHD中与年龄相关的脑异常假说。2）在正常儿童与LD组（LD和LD-ADHD）之间发现了P3潜伏期和波幅的显著组间差异，但在正常儿童与仅患有ADHD的儿童之间未发现显著差异，这表明这些儿童中P3异常的主要相关因素是“加工”问题而非注意力问题。
