Platonov I A
Department of Pharmacology, Smolensk Medical Academy, Russia.
Eksp Klin Farmakol. 1998 Jul-Aug;61(4):51-3.
The search for pathogenetically drugs for the treatment and prevention of edema-swelling of the brain (ESB) is one of the urgent problems of modern biology and medicine. Immune reactions take part in the development of pathological reactions in ESB formation. The antiedemic action of drugs affecting simultaneously the processes in the nervous and immune systems was studied. Such properties are possessed by regular peptides--thymosin fractions. It was demonstrated on a model that the antiedemic effect of thymic peptides under study was due to the influence of the mediator systems: serotonin and adrenergic. The data obtained allowed the antiedemic mechanism of the effect of thymoptin to be associated with its immunostimulating effect. At the same time, the antiedemic effect of thymalin is not connected directly with the immunostimulating action of the drug.
寻找用于治疗和预防脑水肿肿胀（ESB）的致病药物是现代生物学和医学的紧迫问题之一。免疫反应参与了ESB形成过程中的病理反应发展。研究了同时影响神经和免疫系统过程的药物的抗水肿作用。常规肽——胸腺素组分具有这样的特性。在一个模型上证明，所研究的胸腺肽的抗水肿作用是由于介质系统：血清素和肾上腺素能的影响。所获得的数据使胸腺五肽作用的抗水肿机制与其免疫刺激作用相关联。同时，胸腺素的抗水肿作用与该药物的免疫刺激作用没有直接联系。
