Morgenstern B, Atchley W R, Hahn K, Dress A
GSF-National Research Center for Environment and Health, Institute of Biomathematics and Biometry, Neuherberg, Germany.
Proc Int Conf Intell Syst Mol Biol. 1998;6:115-21.
In this paper, we discuss a novel scoring scheme for sequence alignments. The score of an alignment is defined as the sum of so-called weights of aligned segment pairs. A simple modification of the weight function used by the original version of the DIALIGN alignment program turns out to have a crucial advantage: it can be applied to both, global and local alignment problems without the need to specify a threshold parameter.
在本文中，我们讨论了一种用于序列比对的新型评分方案。比对的分数被定义为比对片段对的所谓权重之和。事实证明，对DIALIGN比对程序原始版本所使用的权重函数进行简单修改具有一个关键优势：它可以应用于全局和局部比对问题，而无需指定阈值参数。
