Refsum H E, Bechensteen A G, Lindemann R
Institute for Respiratory Physiology, Ullevål University Hospital, Oslo, Norway.
Pediatr Hematol Oncol. 1998 Sep-Oct;15(5):431-5. doi: 10.3109/08880019809016572.
To evaluate the quantitative aspects of the shift in production from fetal hemoglobin (HbF) to adult hemoglobin (HbA), the HbF and HbA mass were estimated in a preterm infant (gestational age 29 weeks) for 22 weeks after an exchange transfusion the second day of life, leading to an initial HbA% of 100. Up until the estimated time of delivery, the HbA mass declined continuously, at a rate corresponding to a survival time of the transfused HbA erythrocytes of 100 days, and the rise in total hemoglobin mass could be ascribed solely to a rise in the HbF mass. HbF% maximum was reached 3 weeks before HbF mass maximum, and, thus, the HbF% and HbA% time courses gave no basis for evaluation of the production/destruction balance of HbF and HbA erythrocytes. The applied quantitative approach seems to be a useful additional procedure for evaluating the switch from HbF to HbA production and for estimating HbA erythrocyte survival time in preterm infants.
为评估从胎儿血红蛋白（HbF）向成人血红蛋白（HbA）转变过程中的产量定量情况，对一名出生第二天接受换血治疗（初始HbA%为100）的早产儿（胎龄29周）在出生后22周内的HbF和HbA含量进行了估算。直至预计分娩时间，HbA含量持续下降，下降速率对应于所输注HbA红细胞的存活时间为100天，而总血红蛋白含量的升高可完全归因于HbF含量的升高。HbF%在HbF含量达到最大值前3周达到最大值，因此，HbF%和HbA%的时间进程无法为评估HbF和HbA红细胞的生成/破坏平衡提供依据。所应用的定量方法似乎是评估早产儿从HbF向HbA生成转变以及估算HbA红细胞存活时间的一种有用的辅助手段。
