不同成熟度新生儿的血红蛋白A2

Haemoglobin A2 in newborn infants of different maturity.

作者信息

Neumeyer P, Betke K

机构信息

Universitätskinderklinik, Dr. v. Haunerschen Kinderspital, München, Federal Republic of Germany.

出版信息

Eur J Pediatr. 1987 Nov;146(6):598-600. doi: 10.1007/BF02467363.

DOI:10.1007/BF02467363

PMID:2448141

Abstract

From 70 infants born after gestation periods of 28-41 weeks HbF and HbA2 were determined in the cord blood; HbA was calculated from the two values. HbF decreased with maturity, HbA and HbA2 increased. The percentage of HbA2 calculated from the sum of HbA + HbA2 (non-fetal Hb) increased from 0.57% to 0.83% with maturity. These values are much lower than those in adult controls (1.83%). The results show that during development the synthesis of the delta-globin chains lags behind that of the beta-globin chains. This is remarkable considering the location of the delta-globin gene within the beta-globin like gene cluster.

摘要

对70名孕周在28至41周之间出生的婴儿，测定其脐带血中的HbF和HbA2；HbA由这两个值计算得出。HbF随成熟度降低，HbA和HbA2升高。由HbA + HbA2（非胎儿血红蛋白）之和计算得出的HbA2百分比随成熟度从0.57%增至0.83%。这些值远低于成人对照组的值（1.83%）。结果表明，在发育过程中，δ-珠蛋白链的合成落后于β-珠蛋白链。考虑到δ-珠蛋白基因在β-珠蛋白样基因簇中的位置，这一点很值得注意。