Borodaĭ N V, Nosa P P, Penezina O P
Tsitol Genet. 1998 Mar-Apr;32(2):80-7.
The DNA content in epitheliocytes of the mucous membrane of the oral cavity and expression of carcinoembryonic antigen and trophoblast-specific beta-1 glycoprotein on peripheral blood lymphocytes, peripheral blood T-lymphocytes subsets into three groups of patients: 1--diffusion mastopathy; 2--diffusion mastopathy with fibromyoma uteri and 3--fibroadenoma were studied. It was indicated that DNA content was higher in all groups in comparison with healthy women and it was shown that in contrast to healthy women, 45% of patients studied had abnormal rate of T-cells subsets, about 30% of them had abnormal expression of CEA and TSG on peripheral blood lymphocytes. The data obtained show the significant disbalance in the mechanisms of defence and compensation taking place in the organisms of patients with nonmalignant mammary diseases.
对三组患者口腔黏膜上皮细胞中的DNA含量以及外周血淋巴细胞上癌胚抗原和滋养层特异性β-1糖蛋白的表达情况进行了研究：1组——弥漫性乳腺病；2组——伴有子宫纤维瘤的弥漫性乳腺病；3组——纤维腺瘤。结果表明，与健康女性相比，所有组中的DNA含量均较高，并且与健康女性相比，45%的受研究患者T细胞亚群比例异常，其中约30%在外周血淋巴细胞上癌胚抗原和滋养层特异性β-1糖蛋白表达异常。所获得的数据表明，非恶性乳腺疾病患者机体的防御和代偿机制存在明显失衡。
