Klämbt C, Schimmelpfeng K, Hummel T
Institut für Neurobiologie, Universität Münster, Germany.
Invert Neurosci. 1997 Sep-Dec;3(2-3):165-74. doi: 10.1007/BF02480371.
The major axon tracts in the embryonic CNS of Drosophila are organised in a simple, ladder-like pattern. Each neuromere contains two commissures which connect the contra-lateral sides and two longitudinal connectives which connect the different neuromeres along the anterior-posterior axis. The commissures form in close association with only few cells located at the CNS midline. The formation of longitudinal connectives depends in part on the presence of specific lateral glial cells. To unravel the genes underlying the formation of the embryonic CNS axon pattern, we conducted a saturating F2 EMS mutagenesis, screening for mutations, which disrupt this process. The analyses of the identified mutations lead to a simple sequential model on axon pattern formation in embryonic CNS.
果蝇胚胎中枢神经系统中的主要轴突束以简单的梯状模式排列。每个神经节包含两条连接对侧的连合纤维和两条沿前后轴连接不同神经节的纵向连接纤维。连合纤维仅与位于中枢神经系统中线的少数细胞紧密相关形成。纵向连接纤维的形成部分依赖于特定侧胶质细胞的存在。为了揭示胚胎中枢神经系统轴突模式形成背后的基因，我们进行了饱和F2 EMS诱变，筛选破坏这一过程的突变。对已鉴定突变的分析得出了一个关于胚胎中枢神经系统轴突模式形成的简单顺序模型。
