果蝇胚胎中枢神经系统神经胶质细胞的发育与功能

Development and function of embryonic central nervous system glial cells in Drosophila.

作者信息

Klämbt C, Hummel T, Menne T, Sadlowski E, Scholz H, Stollewerk A

机构信息

Institut für Entwicklungsbiologie, Universität zu Köln, Germany.

出版信息

Dev Genet. 1996;18(1):40-9. doi: 10.1002/(SICI)1520-6408(1996)18:1<40::AID-DVG5>3.0.CO;2-1.

DOI:10.1002/(SICI)1520-6408(1996)18:1<40::AID-DVG5>3.0.CO;2-1

PMID:8742833

Abstract

Each abdominal neuromere of a Drosophila embryo contains about 60 glial cells [Klämbt C, Goodman CS (1991): Glia 4:205-213; Ito et al. (1995): Roux's Arch Dev Biol, 204:284-307]. Among these, the midline and longitudinal glia are described to some detail. The midline glia are located dorsally in the nerve cord ensheathing the two segmental commissures. They are required for the proper establishment of commissures. The longitudinal glia, the A and B glia, and the segment boundary cells (SBC) are covering the longitudinal connectives. The longitudinal glia prefigure longitudinal axon paths and appear capable of regulating the expression of neuronal antigens. In the following we summarize the knowledge on the function of these glial cells.

摘要

果蝇胚胎的每个腹部神经节包含约60个神经胶质细胞[克莱姆特C，古德曼CS（1991年）：《神经胶质》4：205 - 213；伊藤等人（1995年）：《鲁克斯发育生物学文献》，204：284 - 307]。其中，中线神经胶质细胞和纵向神经胶质细胞已有一定详细描述。中线神经胶质细胞位于神经索背侧，包绕两个节间连合。它们对于连合的正确形成是必需的。纵向神经胶质细胞、A和B神经胶质细胞以及节边界细胞（SBC）覆盖纵向连接体。纵向神经胶质细胞预示着纵向轴突路径，并且似乎能够调节神经元抗原的表达。在下面，我们总结关于这些神经胶质细胞功能的知识。