Ernst H, Scampini G, Durchfeld-Meyer B, Brander-Weber P, Rittinghausen S
Fraunhofer Institute of Toxicology and Aerosol Research, Hannover, Germany.
Exp Toxicol Pathol. 1998 Sep;50(4-6):384-8. doi: 10.1016/S0940-2993(98)80022-5.
Two cases of odontogenic fibroma occurring in aged Sprague-Dawley rats are described. Both neoplasms were associated with a maxillary incisor and had identical histomorphological features. They were composed of solid proliferations of primitive, dental pulp-like mesenchyme separated by areas of collagenization. Small strands and islands of mainly undifferentiated odontogenic epithelium immunostaining for keratins were scattered throughout both tumours. As a further characteristic, the lesions contained small foci of mineralization which were either cementum-like or resembled dysplastic dentin. The odontogenic fibroma represents a further type of odontogenic tumour in rats, which due to its typical histomorphology, can easily be differentiated from other odontogenic tumours such as ameloblastic odontoma or ameloblastoma.
