Arzi B, Murphy B, Nemec A, Vapniarsky N, Naydan D K, Verstraete F J M
William R. Pritchard Veterinary Medical Teaching Hospital, USA. University of California, Davis, CA 95616, USA.
J Comp Pathol. 2011 Nov;145(4):345-51. doi: 10.1016/j.jcpa.2011.03.003. Epub 2011 Apr 20.
Odontogenic tumours are considered to be relatively rare; however, several histologically distinct types have been identified in dogs. The more common canine odontogenic tumours are peripheral odontogenic fibroma and canine acanthomatous ameloblastoma. The expression of cytokeratins (CKs) has been established for the human dental germ and odontogenic tumours. The aim of the present study was to describe the immunohistochemical expression of a panel of CKs in the epithelium of the canine dental germ, normal gingiva and odontogenic tumours arising in this species. Samples from 20 odontogenic tumours, 12 tooth germs and three normal gingival tissues were obtained. Each sample was stained with haematoxylin and eosin and subjected to immunohistochemistry for CK expression. The typical expression pattern of CKs in the odontogenic epithelium and gingiva of dogs was CK14 and CK5/6. CKs 7, 8, 18 and 20 were generally absent from the canine dental germ, gingiva and odontogenic tumours. Dogs and man therefore exhibit similar CK expression in the odontogenic epithelium.
牙源性肿瘤被认为相对罕见；然而，在犬类中已鉴定出几种组织学上不同的类型。较常见的犬牙源性肿瘤是外周性牙源性纤维瘤和犬棘皮瘤样成釉细胞瘤。细胞角蛋白（CKs）在人类牙胚和牙源性肿瘤中的表达已得到证实。本研究的目的是描述一组CKs在犬牙胚、正常牙龈以及该物种中发生的牙源性肿瘤上皮中的免疫组化表达情况。获取了20个牙源性肿瘤、12个牙胚和3个正常牙龈组织的样本。每个样本用苏木精和伊红染色，并进行CK表达的免疫组化检测。犬牙源性上皮和牙龈中CKs的典型表达模式是CK14和CK5/6。CK7、CK8、CK18和CK20在犬牙胚、牙龈和牙源性肿瘤中通常不存在。因此，犬类和人类在牙源性上皮中表现出相似的CK表达。
