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Sanger Centre, Hinxton Hall, Hinxton, Cambridge CB10 1SA UK.
Science. 1998 Oct 23;282(5389):744-6. doi: 10.1126/science.282.5389.744.
A map of 30,181 human gene-based markers was assembled and integrated with the current genetic map by radiation hybrid mapping. The new gene map contains nearly twice as many genes as the previous release, includes most genes that encode proteins of known function, and is twofold to threefold more accurate than the previous version. A redesigned, more informative and functional World Wide Web site (www.ncbi.nlm.nih.gov/genemap) provides the mapping information and associated data and annotations. This resource constitutes an important infrastructure and tool for the study of complex genetic traits, the positional cloning of disease genes, the cross-referencing of mammalian genomes, and validated human transcribed sequences for large-scale studies of gene expression.
通过辐射杂种作图，构建了一张包含30181个人类基因标记的图谱，并将其与当前的遗传图谱整合。新的基因图谱包含的基因数量几乎是上一版的两倍，涵盖了大多数编码已知功能蛋白质的基因，并且比上一版精确两到三倍。一个重新设计的、信息更丰富且功能更强的万维网站点（www.ncbi.nlm.nih.gov/genemap）提供了图谱信息以及相关数据和注释。该资源构成了研究复杂遗传性状、疾病基因的定位克隆、哺乳动物基因组的交叉参照以及用于大规模基因表达研究的经过验证的人类转录序列的重要基础设施和工具。
