通过破坏结核分枝杆菌erp基因减弱毒力
Attenuation of virulence by disruption of the Mycobacterium tuberculosis erp gene.
作者信息
Berthet F X, Lagranderie M, Gounon P, Laurent-Winter C, Ensergueix D, Chavarot P, Thouron F, Maranghi E, Pelicic V, Portnoï D, Marchal G, Gicquel B
机构信息
Unité de Génétique Mycobactérienne, Institut Pasteur, 25 rue du Docteur Roux, 75724 Paris Cédex 15, France.
出版信息
Science. 1998 Oct 23;282(5389):759-62. doi: 10.1126/science.282.5389.759.
The virulence of the mycobacteria that cause tuberculosis depends on their ability to multiply in mammalian hosts. Disruption of the bacterial erp gene, which encodes the exported repetitive protein, impaired multiplication of M. tuberculosis and M. bovis Bacille Calmette-Guérin in cultured macrophages and mice. Reintroduction of erp into the mutants restored their ability to multiply. These results indicate that erp contributes to the virulence of M. tuberculosis.
导致结核病的分枝杆菌的毒力取决于它们在哺乳动物宿主体内繁殖的能力。编码输出性重复蛋白的细菌erp基因的破坏，损害了结核分枝杆菌和卡介苗在培养的巨噬细胞和小鼠中的繁殖。将erp重新导入突变体中恢复了它们的繁殖能力。这些结果表明，erp有助于结核分枝杆菌的毒力。
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