Comparison of observed and predicted first-pass metabolism of nortriptyline in humans.
作者信息
Niazi S
出版信息
J Pharm Sci. 1976 Oct;65(10):1535-6. doi: 10.1002/jps.2600651031.
PMID:978417
Abstract
The extent of first-pass metabolism of nortriptyline, calculated by comparing the areas under the plasma concentration-time curves following intravenous and oral dosing in six individuals, varied from 41 to 54%. Theoretically predicted values ranged from 41 to 61% based on a plasma flow model, indicating that the clearance takes place mainly from the plasma, which does not represent the whole blood concentration.
摘要
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