Collins J F, Brown J P, Alexeeff G V, Salmon A G
Office of Environmental Health Hazard Assessment, California Environmental Protection Agency, Berkeley, California 94704, USA.
Regul Toxicol Pharmacol. 1998 Aug;28(1):45-54. doi: 10.1006/rtph.1998.1235.
Potency equivalency factors (PEFs) for cancer induction relative to benzo[a]pyrene have been derived for 21 polycyclic aromatic hydrocarbons (PAHs) and PAH derivatives based on a data preference scheme. PEFs have been derived only for PAHs with demonstrated carcinogenicity in bioassays. Cancer potency values and inhalation unit risks are presented for four additional carcinogenic PAHs based on expedited risk assessments conducted for California's Proposition 65. A much larger number of PAHs and PAH derivatives are considered mutagenic or genotoxic and may have limited evidence for carcinogenicity, but these compounds are not considered in this evaluation. New cancer bioassay data and possibly structure-activity analysis may indicate that additional PAHs are carcinogenic. Thus, additional PAHs may be identified as potential human carcinogens when such data become available. However, until that time the PEFs proposed for use in risk assessment were estimated only for PAHs currently classified as carcinogens.
已根据数据优先方案得出了21种多环芳烃（PAH）及其衍生物相对于苯并[a]芘的致癌效力等效因子（PEF）。PEF仅针对在生物测定中已证明具有致癌性的PAH得出。基于为加利福尼亚州第65号提案进行的快速风险评估，给出了另外四种致癌PAH的癌症效力值和吸入单位风险。大量的PAH及其衍生物被认为具有致突变性或基因毒性，可能有有限的致癌证据，但本评估未考虑这些化合物。新的癌症生物测定数据以及可能的构效关系分析可能表明还有其他PAH具有致癌性。因此，当获得此类数据时，可能会识别出更多的PAH作为潜在的人类致癌物。然而，在此之前，提议用于风险评估的PEF仅针对目前归类为致癌物的PAH进行了估算。
