麻风分枝杆菌一种34千道尔顿蛋白的特性，该蛋白与副结核分枝杆菌的免疫显性34千道尔顿抗原同源。
Characterization of a 34-kilodalton protein of Mycobacterium leprae that is isologous to the immunodominant 34-kilodalton antigen of Mycobacterium paratuberculosis.
作者信息
Silbaq F S, Cho S N, Cole S T, Brennan P J
机构信息
Department of Microbiology, Colorado State University, Fort Collins, Colorado 80523, USA.
出版信息
Infect Immun. 1998 Nov;66(11):5576-9. doi: 10.1128/IAI.66.11.5576-5579.1998.
Abstract
During DNA sequence analysis of cosmid L373 from the Mycobacterium leprae genome, an open reading frame of 1.4 kb encoding a protein with some homology to the immunodominant 34-kDa protein of Mycobacterium paratuberculosis, but lacking significant serological activity, was detected. The DNA sequence predicted a signal peptide with a modified lipoprotein consensus sequence, but the protein proved to be devoid of lipid attachment.
摘要
在对麻风分枝杆菌基因组的黏粒L373进行DNA序列分析时，检测到一个1.4 kb的开放阅读框，其编码的蛋白质与副结核分枝杆菌的免疫显性34 kDa蛋白有一定同源性，但缺乏显著的血清学活性。DNA序列预测有一个带有修饰脂蛋白共有序列的信号肽，但该蛋白质被证明没有脂质附着。
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