Lautt W W, Côté M G
J Pharmacol Exp Ther. 1976 Sep;198(3):562-7.
Intraportal injection of 6-hydroxydopamine (25 mg/kg) results in nearly complete functional sympathectomy in the cat liver 1 week after the injection. Functional sympathectomy was verified by comparing the changes in liver blood volume (measured in vivo in a plethysmograph) resulting from direct stimulation of the hepatic nerves in control and pretreated animals. Pretreatment prevented the large reductions in hepatic blood volume normally seen with nerve stimulation while the response to infused noradrenaline was not reduced. Lack of morphological changes in right atrial nerve endings and an unaltered pressor response to bilateral carotid arterial occlusion indicate that sympathectomy at sites other than the liver did not occur.
门静脉注射6-羟基多巴胺（25毫克/千克），在注射1周后可使猫肝脏几乎完全功能性去交感神经支配。通过比较对照动物和预处理动物直接刺激肝神经后肝脏血容量（在体积描记器中体内测量）的变化，验证了功能性去交感神经支配。预处理可防止神经刺激时通常出现的肝脏血容量大幅减少，而对注入去甲肾上腺素的反应并未降低。右心房神经末梢无形态学变化，且对双侧颈动脉闭塞的升压反应未改变，表明肝脏以外部位未发生去交感神经支配。
