Lautt W W, Wong C
Can J Physiol Pharmacol. 1978 Aug;56(4):679-82. doi: 10.1139/y78-111.
Sympathetic nerves to the intact liver of the cat were selectively destroyed by injection of 6-hydroxydopamine into the portal vein 1 week prior to the experiment. Glucose output was calculated from the product of the arterial-venous glucose difference and hepatic blood flow. Hepatic blood flow was monitored by an electromagnetic flowmeter using a hepatic venous long-circuit. Stimulation of the parasympathetic nerves isolated from around the common hepatic artery produced a rapid reduction in hepatic glucose output to one-quarter of control levels by 2 min and to zero by 10 min of nerve stimulation. The data show that hepatic glucose balance is readily influenced by the hepatic parasympathetic nerves.
在实验前1周，通过向门静脉注射6-羟基多巴胺，选择性地破坏了猫完整肝脏的交感神经。葡萄糖输出量通过动脉-静脉葡萄糖差值与肝血流量的乘积来计算。肝血流量通过电磁流量计使用肝静脉长循环进行监测。刺激从肝总动脉周围分离出的副交感神经，在神经刺激2分钟时，肝葡萄糖输出迅速降至对照水平的四分之一，在10分钟时降至零。数据表明，肝脏葡萄糖平衡很容易受到肝脏副交感神经的影响。
