Taranto M P, Medici M, Perdigon G, Ruiz Holgado A P, Valdez G F
Centro de Referencia para Lactobacilos (CERELA), San Miguel de Tucumán, Argentina.
J Dairy Sci. 1998 Sep;81(9):2336-40. doi: 10.3168/jds.S0022-0302(98)70123-7.
Swiss Albino mice were fed a diet enriched with fat to produce hypercholesterolemia. The further administration of Lactobacillus reuteri CRL 1098 (10(4) cells/d) to hypercholesterolemic mice for 7 d decreased total cholesterol by 38%, producing serum cholesterol concentrations similar to that of the control group (67.4 mg/ml). This low dose of L. reuteri caused a 40% reduction in triglycerides and a 20% increase in the ratio of high density lipoprotein to low density lipoprotein without bacterial translocation of the native microflora into the spleen and liver. These data suggest that L. reuteri CRL 1098 is an effective hypocholesterolemic adjuvant at a low cell concentration for mice.
给瑞士白化小鼠喂食富含脂肪的饮食以诱发高胆固醇血症。对高胆固醇血症小鼠进一步给予罗伊氏乳杆菌CRL 1098（10⁴ 个细胞/天），持续7天，可使总胆固醇降低38%，产生的血清胆固醇浓度与对照组相似（67.4毫克/毫升）。这种低剂量的罗伊氏乳杆菌使甘油三酯降低40%，高密度脂蛋白与低密度脂蛋白的比率增加20%，且原生微生物群不会发生向脾脏和肝脏的细菌易位。这些数据表明，罗伊氏乳杆菌CRL 1098在低细胞浓度下对小鼠是一种有效的降胆固醇佐剂。
