Mercanligil S M, Arslan P, Alasalvar C, Okut E, Akgül E, Pinar A, Geyik P O, Tokgözoğlu L, Shahidi F
Department of Nutrition and Dietetics, Hacettepe University, Ankara, Turkey.
Eur J Clin Nutr. 2007 Feb;61(2):212-20. doi: 10.1038/sj.ejcn.1602518. Epub 2006 Sep 13.
Frequent consumption of nuts is associated with favorable plasma lipid profiles and reduced risk of coronary heart disease (CHD). This study was conducted to investigate the effects of hazelnut-enriched diet on plasma cholesterol and lipoprotein profiles in hypercholesterolemic adult men compared with baseline and control diet, and also to measure the anthropometric parameters, habitual physical activities, nutrient intake and endothelial function.
Fifteen hypercholesterolemic men aged 48+/-8 years were recruited voluntarily. A well-controlled, 2-period (P1 and P2) study design with a total of 8-week was implemented. In the P1, subjects consumed a control diet (low-fat, low-cholesterol and high-carbohydrate). During the P2, the control diet was supplemented with MUFA-rich hazelnut (40 g/day), which provided 11.6% of total energy content. Anthropometric parameters and habitual physical activities were recorded. Plasma total and HDL cholesterol, TAG, ApoA-1, Apo B, total homocysteine and glucose concentrations were measured. All parameters and measurements were obtained at baseline and end of each 4-week diet period.
Body weights of subjects remained stable throughout the study. Compared with baseline, the hazelnut-enriched diet decreased (P<0.05) the concentrations of VLDL cholesterol, triacylglycerol, apolipoprotein B by 29.5, 31.8, and 9.2%, respectively, while increasing HDL cholesterol concentrations by 12.6%. Total/HDL cholesterol and LDL/HDL cholesterol ratios favorably decreased (P<0.05). Although insignificant there was a decreasing trend for the rest of parameters, particularly in total (5.2%) and LDL cholesterol (3.3%) in subjects consuming a hazelnut-enriched diet compared to that of the baseline. No changes were found in fasting levels of glucose, Apo A-1 and homocysteine between the control and hazelnut-enriched diets.
This study demonstrated that a high-fat and high-MUFA-rich hazelnut diet was superior to a low-fat control diet because of favorable changes in plasma lipid profiles of hypercholesterolemic adult men and, thereby positively affecting the CHD risk profile.
Funding provided by a grant from the Hazelnut Promotion Group, Giresun, Turkey.
经常食用坚果与良好的血脂水平及降低冠心病（CHD）风险相关。本研究旨在调查富含榛子的饮食对高胆固醇血症成年男性血浆胆固醇和脂蛋白水平的影响，并与基线和对照饮食进行比较，同时测量人体测量参数、习惯性身体活动、营养摄入和内皮功能。
自愿招募了15名年龄在48±8岁的高胆固醇血症男性。实施了一项严格控制的、为期2个阶段（P1和P2）共8周的研究设计。在P1阶段，受试者食用对照饮食（低脂、低胆固醇和高碳水化合物）。在P2阶段，对照饮食中添加了富含单不饱和脂肪酸（MUFA）的榛子（40克/天），其提供了总能量的11.6%。记录人体测量参数和习惯性身体活动。测量血浆总胆固醇和高密度脂蛋白胆固醇、甘油三酯、载脂蛋白A-1、载脂蛋白B、总同型半胱氨酸和葡萄糖浓度。所有参数和测量值均在基线和每个4周饮食期结束时获取。
在整个研究过程中，受试者的体重保持稳定。与基线相比，富含榛子的饮食使极低密度脂蛋白胆固醇、甘油三酯、载脂蛋白B的浓度分别降低了29.5%、31.8%和9.2%（P<0.05），同时高密度脂蛋白胆固醇浓度增加了12.6%。总胆固醇/高密度脂蛋白胆固醇和低密度脂蛋白胆固醇/高密度脂蛋白胆固醇比值呈有利下降（P<0.05）。虽然其他参数的变化不显著，但与基线相比，食用富含榛子饮食的受试者中，其余参数有下降趋势，尤其是总胆固醇（5.2%）和低密度脂蛋白胆固醇（3.3%）。对照饮食和富含榛子的饮食之间，空腹血糖、载脂蛋白A-1和同型半胱氨酸水平没有变化。
本研究表明，高脂肪和高MUFA含量的榛子饮食优于低脂对照饮食，因为它能使高胆固醇血症成年男性的血浆脂质水平发生有利变化，从而对冠心病风险状况产生积极影响。
由土耳其吉雷松榛子推广集团提供的资助。
