Arntzen K J, Brekke O L, Vatten L, Austgulen R
Institute of Cancer Research and Molecular Biology, University Hospital, Trondheim.
Prostaglandins Other Lipid Mediat. 1998 Jun;56(2-3):183-95. doi: 10.1016/s0090-6980(98)00048-3.
A diet rich in n-3 polyunsaturated fatty acid (PUFA) may reduce the intrauterine production of prostaglandins and prolong pregnancy. We tested this hypothesis by assessing the influence of various PUFAs on the spontaneous production of PGE2 and PGF2 alpha from decidual cell cultures. In addition, we assessed prostaglandin and cytokine production stimulated by lipopolysaccharides (LPS) in order to mimic parturition where infection is involved. In both settings, we found that after supplementing with n-3 PUFA, PGE2 and PGF2 alpha were significantly reduced. After supplementing with n-6 PUFA, there was a significant increase in both prostaglandins. Both n-3 and n-6 PUFAs reduced the production of interleukin 1 (IL-1), while n-6 PUFAs reduced TNF production. PUFAs did not influence IL-6 production. Our findings support the hypothesis that dietary n-3 PUFA may prolong pregnancy by reducing intrauterine production of prostaglandins.
富含n-3多不饱和脂肪酸（PUFA）的饮食可能会减少子宫内前列腺素的产生并延长孕期。我们通过评估各种PUFA对蜕膜细胞培养物中PGE2和PGF2α自发产生的影响来验证这一假设。此外，我们评估了脂多糖（LPS）刺激下的前列腺素和细胞因子产生情况，以模拟涉及感染的分娩过程。在这两种情况下，我们发现补充n-3 PUFA后，PGE2和PGF2α显著减少。补充n-6 PUFA后，两种前列腺素均显著增加。n-3和n-6 PUFA均降低了白细胞介素1（IL-1）的产生，而n-6 PUFA降低了肿瘤坏死因子的产生。PUFA不影响IL-6的产生。我们的研究结果支持以下假设：饮食中的n-3 PUFA可能通过减少子宫内前列腺素的产生来延长孕期。
