Kishko Ia H, Mukvych M S
Zabolotny Institute of Microbiology and Virology, National Academy of Sciences of Ukraine, Kyiv.
Mikrobiol Z. 1998 May-Jun;60(3):70-9.
On the basis of experimental studies which proved stimulating action on absorbing and bactericidal function of blood phagocytes and antibody genesis the methods of therapy and prophylaxis of wide spread infections in modern live-stock (transmissive gastroenteritis of pigs, parainfluenza of calves, colibacteriosis of swine and cattle) were created. It was established, that optimal one-time therapeutical dose of homologous alpha-IFN for intramuscular administration to new-born pigs was 2000-4000 IU per head, prophylactic dose was 1000-2000 IU. Therapeutical doses of alpha-IFN for calves did not exceed 4000-6000 IU, prophylactic--4000 IU. As a rule, it is necessary to introduce the preparation three times with 48 h intervals. With the account of these data the large-scale commissional trials of these preparations were carried out.
基于实验研究证明了对血液吞噬细胞的吸收和杀菌功能以及抗体产生有刺激作用，创建了现代家畜中广泛传播感染（猪传染性胃肠炎、犊牛副流感、猪和牛的大肠杆菌病）的治疗和预防方法。已确定，新生仔猪肌肉注射同源α-干扰素的最佳一次性治疗剂量为每头2000 - 4000国际单位，预防剂量为1000 - 2000国际单位。犊牛的α-干扰素治疗剂量不超过4000 - 6000国际单位，预防剂量为4000国际单位。通常，有必要每隔48小时注射三次该制剂。根据这些数据，对这些制剂进行了大规模的委托试验。
