持续输注五肽胃泌素期间胃酸分泌“消退”的可能机制。
The possible mechanism for the 'fade' in acid gastric secretion during continuous infusions of pentagastrin.
作者信息
Sanyal A K, Waton N G
出版信息
J Physiol. 1976 Oct;261(2):445-51. doi: 10.1113/jphysiol.1976.sp011567.
Abstract
- The 'fade' phenomenon seen in acid gastric secretion in response to a continuous intravenous infusion of pentagastrin has been studied in anaesthetized cats. Whereas acid secretion to a continuous infusion of histamine steadily increased for 3 hr, that to pentagastrin infusion rose steeply to a maximum at 45 min and then decreased gradually to reach about 60% of maximum after 2 hr. 2. Pre-treatment of the cats with the 5-hydroxytryptamine (5-HT) blocking drugs, methysergide and cyproheptadine or with the 5-hydroxytryptamine-depleting drug reserpine completely altered the pattern of secretion to pentagastrin such that the response was similar to that seen during an infusion of histamine. These drugs did not affect secretion stimulated by histamine. 3. It is suggested from these results that pentagastrin releases 5-hydroxytryptamine which at first potentiates and then inhibits the resulting stimulated secretion.
摘要
- 已在麻醉猫身上研究了持续静脉输注五肽胃泌素时胃酸分泌出现的“消退”现象。持续输注组胺时胃酸分泌在3小时内稳步增加，而输注五肽胃泌素时胃酸分泌在45分钟时急剧上升至最大值，然后逐渐下降，2小时后降至最大值的约60%。2. 用5-羟色胺（5-HT）阻断药物麦角新碱和赛庚啶或用5-羟色胺耗竭药物利血平对猫进行预处理，完全改变了对五肽胃泌素的分泌模式，使得反应类似于输注组胺期间所见的反应。这些药物不影响组胺刺激的分泌。3. 从这些结果表明，五肽胃泌素释放5-羟色胺，其起初增强然后抑制由此产生的刺激分泌。
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Gastroenterology. 1962 Jan;42:48-55.
2
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Ir J Med Sci. 1964 May;461:191-201. doi: 10.1007/BF02945775.
3
Inhibition of gastric secretion by extracts containing gastrin.含胃泌素提取物对胃酸分泌的抑制作用。
Gastroenterology. 1963 Mar;44:301-10.
4
The effects of 5-hydroxytryptamine on gastric secretion in anaesthetized dogs.5-羟色胺对麻醉犬胃液分泌的影响。
J Physiol. 1958 Apr 3;141(1):27-34. doi: 10.1113/jphysiol.1958.sp005952.
5
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6
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7
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