持续输注五肽胃泌素期间胃酸分泌“消退”的可能机制。
The possible mechanism for the 'fade' in acid gastric secretion during continuous infusions of pentagastrin.
作者信息
Sanyal A K, Waton N G
出版信息
J Physiol. 1976 Oct;261(2):445-51. doi: 10.1113/jphysiol.1976.sp011567.
Abstract
- The 'fade' phenomenon seen in acid gastric secretion in response to a continuous intravenous infusion of pentagastrin has been studied in anaesthetized cats. Whereas acid secretion to a continuous infusion of histamine steadily increased for 3 hr, that to pentagastrin infusion rose steeply to a maximum at 45 min and then decreased gradually to reach about 60% of maximum after 2 hr. 2. Pre-treatment of the cats with the 5-hydroxytryptamine (5-HT) blocking drugs, methysergide and cyproheptadine or with the 5-hydroxytryptamine-depleting drug reserpine completely altered the pattern of secretion to pentagastrin such that the response was similar to that seen during an infusion of histamine. These drugs did not affect secretion stimulated by histamine. 3. It is suggested from these results that pentagastrin releases 5-hydroxytryptamine which at first potentiates and then inhibits the resulting stimulated secretion.
摘要
- 已在麻醉猫身上研究了持续静脉输注五肽胃泌素时胃酸分泌出现的“消退”现象。持续输注组胺时胃酸分泌在3小时内稳步增加，而输注五肽胃泌素时胃酸分泌在45分钟时急剧上升至最大值，然后逐渐下降，2小时后降至最大值的约60%。2. 用5-羟色胺（5-HT）阻断药物麦角新碱和赛庚啶或用5-羟色胺耗竭药物利血平对猫进行预处理，完全改变了对五肽胃泌素的分泌模式，使得反应类似于输注组胺期间所见的反应。这些药物不影响组胺刺激的分泌。3. 从这些结果表明，五肽胃泌素释放5-羟色胺，其起初增强然后抑制由此产生的刺激分泌。
相似文献
1
The possible mechanism for the 'fade' in acid gastric secretion during continuous infusions of pentagastrin.持续输注五肽胃泌素期间胃酸分泌“消退”的可能机制。
J Physiol. 1976 Oct;261(2):445-51. doi: 10.1113/jphysiol.1976.sp011567.
2
Release of 5-hydroxytryptamine by pentagastrin and its role in the 'fade' of stimulated gastric secretion in cats.
J Physiol. 1987 Feb;383:499-507. doi: 10.1113/jphysiol.1987.sp016424.
3
Investigation of mechanism of fade of gastrin-stimulated gastric acid secretion in the cat.猫胃泌素刺激胃酸分泌消退机制的研究。
J Physiol. 1988 Jan;395:319-31. doi: 10.1113/jphysiol.1988.sp016921.
4
The effects of somatostatin and metiamide on tachyphylaxis of pentagastrin stimulated gastric acid and pepsin secretion in the conscious cat.生长抑素和甲硫咪特对清醒猫中五肽胃泌素刺激的胃酸和胃蛋白酶分泌快速耐受的影响。
J Physiol. 1977 Apr;266(3):801-17. doi: 10.1113/jphysiol.1977.sp011794.
5
Characteristics and tachyphylaxis of gastrin-stimulated gastric acid secretion in the cat.猫胃泌素刺激胃酸分泌的特征及快速耐受性
J Physiol. 1978 Mar;276:1-11. doi: 10.1113/jphysiol.1978.sp012216.
6
The metabolism of [14C]histamine during pentagastrin-stimulated acid secretion in the cat.猫在五肽胃泌素刺激胃酸分泌过程中[14C]组胺的代谢
J Physiol. 1978 Jul;280:389-403. doi: 10.1113/jphysiol.1978.sp012390.
7
The effect of anaesthesia on pentagastrin stimulated gastric acid secretion in the cat.麻醉对猫五肽胃泌素刺激胃酸分泌的影响。
J Physiol. 1978 Jan;274:1-8. doi: 10.1113/jphysiol.1978.sp012129.
8
Inhibition of gastric secretion by pentagastrin.
J Physiol. 1972 Apr;222(1):47P-48P.
9
Action of serotonin on gastric (proventriculus) secretion in chickens.血清素对鸡胃（腺胃）分泌的作用。
Comp Gen Pharmacol. 1971 Jun;2(6):145-50. doi: 10.1016/0010-4035(71)90004-8.
10
Effect of graded doses of methysergide on basal and pentagastrin stimulated gastric secretion in anaesthetised rats.
Indian J Exp Biol. 1996 Feb;34(2):115-7.
引用本文的文献
1
Release of 5-hydroxytryptamine by pentagastrin and its role in the 'fade' of stimulated gastric secretion in cats.
J Physiol. 1987 Feb;383:499-507. doi: 10.1113/jphysiol.1987.sp016424.
2
Investigation of mechanism of fade of gastrin-stimulated gastric acid secretion in the cat.猫胃泌素刺激胃酸分泌消退机制的研究。
J Physiol. 1988 Jan;395:319-31. doi: 10.1113/jphysiol.1988.sp016921.
3
Comparison of the action of cholinomimetics and pentagastrin on gastric secretion in dogs.拟胆碱药与五肽胃泌素对犬胃液分泌作用的比较。
Br J Pharmacol. 1985 Feb;84(2):347-55. doi: 10.1111/j.1476-5381.1985.tb12919.x.
4
Acid secretion from the completely isolated blood perfused canine stomach.完全分离的、由血液灌注的犬胃的胃酸分泌
J Physiol. 1979 Nov;296:113-23. doi: 10.1113/jphysiol.1979.sp012994.
5
The effects of somatostatin and metiamide on tachyphylaxis of pentagastrin stimulated gastric acid and pepsin secretion in the conscious cat.生长抑素和甲硫咪特对清醒猫中五肽胃泌素刺激的胃酸和胃蛋白酶分泌快速耐受的影响。
J Physiol. 1977 Apr;266(3):801-17. doi: 10.1113/jphysiol.1977.sp011794.
本文引用的文献
1
Chemical and histologic demonstration of hydrochloric acid-induced release of serotonin from intestinal mucosa.盐酸诱导肠道黏膜释放5-羟色胺的化学与组织学证明
Gastroenterology. 1962 Jan;42:48-55.
2
THE POSSIBLE ROLE OF 5-HYDROXY TRYPTAMINE IN THE CONTROL OF GASTRIC ACID SECRETION: A NEW CONCEPT.5-羟色胺在胃酸分泌调控中的可能作用：一个新概念
Ir J Med Sci. 1964 May;461:191-201. doi: 10.1007/BF02945775.
3
Inhibition of gastric secretion by extracts containing gastrin.含胃泌素提取物对胃酸分泌的抑制作用。
Gastroenterology. 1963 Mar;44:301-10.
4
The effects of 5-hydroxytryptamine on gastric secretion in anaesthetized dogs.5-羟色胺对麻醉犬胃液分泌的影响。
J Physiol. 1958 Apr 3;141(1):27-34. doi: 10.1113/jphysiol.1958.sp005952.
5
Effect of serotonin (5-hydroxytryptamine) and related compounds on gastric secretion and intestinal motility in the dog.血清素（5-羟色胺）及相关化合物对犬胃液分泌和肠道运动的影响。
Gastroenterology. 1957 Jun;32(6):1058-65.
6
Release of blood platelet serotonin by reserpine and lack of effect on bleeding time.
J Pharmacol Exp Ther. 1956 Jun;117(2):232-6.
7
Structure-function relationships in the active C-terminal tetrapeptide sequence of gastrin.胃泌素活性C末端四肽序列中的结构-功能关系
Nature. 1965 Sep 25;207(5004):1356-9. doi: 10.1038/2071356a0.
8
Effect of exogenous and endogenous secretin on gastric and pancreatic secretion in cats.外源性和内源性促胰液素对猫胃和胰腺分泌的影响。
Am J Physiol. 1969 Oct;217(4):1110-3. doi: 10.1152/ajplegacy.1969.217.4.1110.
9
Effect of secretin on acid and pepsin secretion in cat and dog.促胰液素对猫和狗胃酸及胃蛋白酶分泌的影响。
Gastroenterology. 1969 Mar;56(3):468-75.
10
Peptic ulcer: a reappraisal of its aetiology.
Ann R Coll Surg Engl. 1972 Mar;50(3):145-63.
Zotero 插件