麻醉对猫五肽胃泌素刺激胃酸分泌的影响。
The effect of anaesthesia on pentagastrin stimulated gastric acid secretion in the cat.
作者信息
Albinus M, Blair E L, Hirst B H, Reed J D
出版信息
J Physiol. 1978 Jan;274:1-8. doi: 10.1113/jphysiol.1978.sp012129.
Abstract
- The effect of Saffan (alphaxalone and alphadolone acetate) and Nembutal (pentobarbitone) anaesthesia on gastric acid secretion stimulated by I.V. bolus injections of pentagastrin was investigated in the gastric fistula cat. The effect of Saffan anaesthesia was also tested on I.V. near-maximal and sub-maximal infusions of pentagastrin. 2. Neither anaesthetic reduced the acid secreted in response to bolus injections of pentagastrin. Increased acid secretion with the anaesthetic was noted at some doses of pentagastrin in both intact and vagotomized animals. 3. Saffan anaesthesia had no effect on near-maximal gastric acid secretion stimulated by pentagastrin 8 microgram kg-1 hr-1 but increased the response to pentagastrin 1 microgram kg-1 hr-1. 4. It is suggested that the differences in the acid secretory responses of the anaesthetized acutely prepared animal compared with the conscious animal are a consequence of the surgical procedures rather than the state of consciousness.
摘要
- 在胃瘘猫身上研究了沙夫烷（α-羟孕酮和醋酸α-孕烷二醇）和戊巴比妥（戊巴比妥钠）麻醉对静脉注射五肽胃泌素刺激胃酸分泌的影响。还测试了沙夫烷麻醉对静脉注射接近最大剂量和次最大剂量五肽胃泌素的影响。2. 两种麻醉剂均未减少对静脉注射五肽胃泌素产生的胃酸分泌。在完整和迷走神经切断的动物中，在某些五肽胃泌素剂量下，麻醉剂会导致胃酸分泌增加。3. 沙夫烷麻醉对8微克/千克·小时的五肽胃泌素刺激的接近最大胃酸分泌没有影响，但增加了对1微克/千克·小时的五肽胃泌素的反应。4. 有人认为，与清醒动物相比，急性制备的麻醉动物胃酸分泌反应的差异是手术操作的结果，而非意识状态的结果。
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