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1
A new method for labelling saxitoxin and its binding to non-myelinated fibres of the rabbit vagus, lobster walking leg, and garfish olfactory nerves.一种标记石房蛤毒素及其与兔迷走神经、龙虾步足和雀鳝嗅神经无髓纤维结合的新方法。
J Physiol. 1976 Oct;261(2):477-94. doi: 10.1113/jphysiol.1976.sp011569.
2
The binding of labelled saxitoxin to the sodium channels in nerve membranes.标记的石房蛤毒素与神经膜中钠通道的结合。
J Physiol. 1973 Dec;235(3):783-804. doi: 10.1113/jphysiol.1973.sp010417.
3
The binding of labelled tetrodotoxin to non-myelinated nerve fibres.标记的河豚毒素与无髓神经纤维的结合。
J Physiol. 1972 Dec;227(1):95-126. doi: 10.1113/jphysiol.1972.sp010022.
4
Binding of tetrodotoxin and saxitoxin to sodium channels.河豚毒素和石房蛤毒素与钠通道的结合。
Philos Trans R Soc Lond B Biol Sci. 1975 Jun 10;270(908):319-36. doi: 10.1098/rstb.1975.0012.
5
Saxitoxin binding in nerves from walking legs of the lobster Homarus americanus. Two classes of receptors.美洲螯龙虾步足神经中石房蛤毒素的结合。两类受体。
J Gen Physiol. 1981 Feb;77(2):205-21. doi: 10.1085/jgp.77.2.205.
6
Evidence that tetrodotoxin and saxitoxin act at a metal cation binding site in the sodium channels of nerve membrane.河豚毒素和石房蛤毒素作用于神经膜钠通道中金属阳离子结合位点的证据。
Proc Natl Acad Sci U S A. 1974 Oct;71(10):3936-40. doi: 10.1073/pnas.71.10.3936.
7
Saxitoxin binding to sodium channels of rat skeletal muscles.石房蛤毒素与大鼠骨骼肌钠通道的结合。
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8
The binding of tritium-labelled tetrodotoxin to non-myelinated nerve.氚标记的河豚毒素与无髓神经的结合。
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9
Components of the plasma membrane of growing axons. III. Saxitoxin binding to sodium channels.生长中轴突的质膜成分。III. 石房蛤毒素与钠通道的结合
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10
The binding of tetrodotoxin to nerve membranes.河豚毒素与神经膜的结合。
J Physiol. 1971 Feb;213(1):235-54. doi: 10.1113/jphysiol.1971.sp009379.

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1
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2
Finding Channels.寻找通道。
J Biol Chem. 2015 Nov 20;290(47):28357-28373. doi: 10.1074/jbc.X115.683383. Epub 2015 Oct 2.
3
The dependence of auditory nerve rate adaptation on electric stimulus parameters, electrode position, and fiber diameter: a computer model study.听觉神经频率适应对电刺激参数、电极位置和纤维直径的依赖性：计算机模型研究。
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4
Tetrodotoxin: a brief history.河豚毒素：简史
Proc Jpn Acad Ser B Phys Biol Sci. 2008;84(5):147-54. doi: 10.2183/pjab.84.147.
5
Composition of axolemma-enriched fractions isolated from bovine CNS myelinated axons.从牛中枢神经系统有髓轴突中分离出的富含轴膜组分的成分。
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6
Components of the plasma membrane of growing axons. III. Saxitoxin binding to sodium channels.生长中轴突的质膜成分。III. 石房蛤毒素与钠通道的结合
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7
Electrical activity and cytosolic calcium regulate levels of tetrodotoxin-sensitive sodium channels in cultured rat muscle cells.电活动和胞质钙调节培养的大鼠肌肉细胞中对河豚毒素敏感的钠通道水平。
Proc Natl Acad Sci U S A. 1984 Jan;81(1):262-6. doi: 10.1073/pnas.81.1.262.
8
Identification of two sodium channel subtypes in chick heart and brain.鸡心脏和大脑中两种钠通道亚型的鉴定。
Proc Natl Acad Sci U S A. 1983 Feb;80(4):1106-10. doi: 10.1073/pnas.80.4.1106.
9
Sodium currents in the giant axon of the crab Carcinus maenas.海蟹（Carcinus maenas）巨轴突中的钠电流。
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10
Isolation and characterization of a monoclonal antibody against the saxitoxin-binding component from the electric organ of the eel Electrophorus electricus.
Proc Natl Acad Sci U S A. 1982 Mar;79(5):1673-7. doi: 10.1073/pnas.79.5.1673.

本文引用的文献

1
Movements of Na and K in single muscle fibres.单根肌纤维中钠和钾的运动。
J Physiol. 1959 Mar 3;145(2):405-32. doi: 10.1113/jphysiol.1959.sp006150.
2
An upper limit to the number of sodium channels in nerve membrane?神经膜中钠通道数量的上限？
J Physiol. 1967 Jan;188(1):99-105. doi: 10.1113/jphysiol.1967.sp008126.
3
The movements of labelled ions in mammalian non-myelinated nerve fibres.标记离子在哺乳动物无髓神经纤维中的运动。
J Physiol. 1965 Jul;179(2):333-67. doi: 10.1113/jphysiol.1965.sp007666.
4
The origin of the initial heat associated with a single impulse in mammalian non-myelinated nerve fibres.哺乳动物无髓神经纤维中单个冲动相关的初始热的起源。
J Physiol. 1968 Feb;194(3):745-93. doi: 10.1113/jphysiol.1968.sp008434.
5
The binding of tetrodotoxin to nerve membranes.河豚毒素与神经膜的结合。
J Physiol. 1971 Feb;213(1):235-54. doi: 10.1113/jphysiol.1971.sp009379.
6
Garfish olfactory nerve: easily accessible source of numerous long, homogeneous, nonmyelinated axons.雀鳝嗅神经：众多长的、均匀的、无髓鞘轴突的容易获取的来源。
Science. 1971 May 28;172(3986):952-5. doi: 10.1126/science.172.3986.952.
7
Binding of radioactive tetrodotoxin to nerve membrane preparations.放射性河豚毒素与神经膜制剂的结合
Biochim Biophys Acta. 1972 May 9;266(2):548-56. doi: 10.1016/0005-2736(72)90110-1.
8
The interaction at equilibrium between tetrodotoxin and mammalian non-myelinated nerve fibres.河豚毒素与哺乳动物无髓神经纤维在平衡状态下的相互作用。
J Physiol. 1972 Mar;221(3):533-53. doi: 10.1113/jphysiol.1972.sp009766.
9
The binding of labelled saxitoxin to the sodium channels in nerve membranes.标记的石房蛤毒素与神经膜中钠通道的结合。
J Physiol. 1973 Dec;235(3):783-804. doi: 10.1113/jphysiol.1973.sp010417.
10
The binding of labelled tetrodotoxin to non-myelinated nerve fibres.标记的河豚毒素与无髓神经纤维的结合。
J Physiol. 1972 Dec;227(1):95-126. doi: 10.1113/jphysiol.1972.sp010022.

一种标记石房蛤毒素及其与兔迷走神经、龙虾步足和雀鳝嗅神经无髓纤维结合的新方法。

A new method for labelling saxitoxin and its binding to non-myelinated fibres of the rabbit vagus, lobster walking leg, and garfish olfactory nerves.

作者信息

Ritchie J M, Rogart R B, Strichartz G R

出版信息

J Physiol. 1976 Oct;261(2):477-94. doi: 10.1113/jphysiol.1976.sp011569.

DOI:10.1113/jphysiol.1976.sp011569
PMID:978583
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1309152/
Abstract
  1. A new method of labelling saxitoxin (STX) is described, based on transfer of tritium from tritiated water to the toxin. 2. The radiochemical purity of the labelled toxin has been directly determined, rather than being based on indirect biochemical means, as in previous experiments with Wilzbach-labelled STX and TTX. 3. The specific activity of the labelled toxin, 66 d..m.f-mole-1, corresponds with one tritium atom per molecule STX, an improvement of about 300-fold over other means of labelling TTX and STX. 4. The binding of this toxin to rabbit, lobster and garfish olfactory nerve fibres has been re-examined. 5. The density of sodium channels calculated on the basis of the binding of the toxin is about four to six-times the values previously reported.
摘要
  1. 描述了一种标记石房蛤毒素（STX）的新方法，该方法基于氚从氚化水转移到毒素上。2. 已直接测定了标记毒素的放射化学纯度，而不是像之前用威尔茨巴赫法标记STX和TTX的实验那样基于间接生化手段。3. 标记毒素的比活为66 d..m.f-mole-1，相当于每个STX分子有一个氚原子，比其他标记TTX和STX的方法提高了约300倍。4. 重新研究了这种毒素与兔、龙虾和雀鳝嗅神经纤维的结合。5. 根据毒素结合计算出的钠通道密度约为先前报道值的四到六倍。