Hunter P J, McCulloch A D, ter Keurs H E
Department of Engineering Science, University of Auckland, New Zealand.
Prog Biophys Mol Biol. 1998;69(2-3):289-331. doi: 10.1016/s0079-6107(98)00013-3.
A model of passive and active cardiac muscle mechanics is presented, suitable for use in continuum mechanics models of the whole heart. The model is based on an extensive review of experimental data from a variety of preparations (intact trabeculae, skinned fibres and myofibrils) and species (mainly rat and ferret) at temperatures from 20 to 27 degrees C. Experimental tests include isometric tension development, isotonic loading, quick-release/restretch, length step and sinusoidal perturbations. We show that all of these experiments can be interpreted with a four state variable model which includes (i) the passive elasticity of myocardial tissue, (ii) the rapid binding of Ca2+ to troponin C and its slower tension-dependent release, (iii) the kinetics of tropomyosin movement and availability of crossbridge binding sites and the length dependence of this process and (iv) the kinetics of crossbridge tension development under perturbations of myofilament length.
提出了一种被动和主动心肌力学模型，适用于全心脏的连续介质力学模型。该模型基于对来自各种标本（完整小梁、去垢剂处理的纤维和肌原纤维）以及不同物种（主要是大鼠和雪貂）在20至27摄氏度温度下的实验数据的广泛综述。实验测试包括等长张力发展、等张加载、快速释放/再拉伸、长度阶跃和正弦扰动。我们表明，所有这些实验都可以用一个四状态变量模型来解释，该模型包括：（i）心肌组织的被动弹性；（ii）Ca2+与肌钙蛋白C的快速结合及其较慢的张力依赖性释放；（iii）原肌球蛋白运动动力学和横桥结合位点的可用性以及该过程的长度依赖性；（iv）在肌丝长度扰动下横桥张力发展的动力学。
