Villalobos Lizardi José Carlos, Baranger Jerome, Nguyen Minh B, Asnacios Atef, Malik Aimen, Lumens Joost, Mertens Luc, Friedberg Mark K, Simmons Craig A, Pernot Mathieu, Villemain Olivier
Division of Cardiology, Department of Pediatrics, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.
Laboratoire Matière et Systèmes Complexes, CNRS UMR 7057, Université de Paris, Paris, France.
Nat Cardiovasc Res. 2022 Jan;1(1):8-22. doi: 10.1038/s44161-021-00007-3. Epub 2022 Jan 12.
Myocardial stiffness is an intrinsic property of the myocardium that influences both diastolic and systolic cardiac function. Myocardial stiffness represents the resistance of this tissue to being deformed and depends on intracellular components of the cardiomyocyte, particularly the cytoskeleton, and on extracellular components, such as collagen fibers. Myocardial disease is associated with changes in myocardial stiffness, and its assessment is a key diagnostic marker of acute or chronic pathological myocardial disease with the potential to guide therapeutic decision-making. In this Review, we appraise the different techniques that can be used to estimate myocardial stiffness, evaluate their advantages and disadvantages, and discuss potential clinical applications.
心肌僵硬度是心肌的一种内在特性，它会影响心脏的舒张和收缩功能。心肌僵硬度代表了该组织对变形的抵抗能力，并且取决于心肌细胞的细胞内成分，特别是细胞骨架，以及细胞外成分，如胶原纤维。心肌疾病与心肌僵硬度的变化有关，对其评估是急性或慢性病理性心肌疾病的关键诊断标志物，有可能指导治疗决策。在本综述中，我们评估了可用于估计心肌僵硬度的不同技术，评估了它们的优缺点，并讨论了潜在的临床应用。
