Parker A, Gaffan D
Department of Experimental Psychology, Oxford University, UK.
Eur J Neurosci. 1998 Oct;10(10):3044-57. doi: 10.1046/j.1460-9568.1998.00306.x.
Monkeys were trained preoperatively in visual object recognition memory. The task was delayed matching-to-sample with lists of trial-unique randomly generated visual stimuli in an automated apparatus, and the stimuli were 2D visual objects made from randomly generated coloured shapes. We then examined the effect of either: (i) disconnecting the frontal cortex in one hemisphere from the perirhinal cortex in the contralateral hemisphere by crossed unilateral ablations; (ii) disconnecting the magnocellular portion of the mediodorsal (MDmc) thalamic nucleus in one hemisphere from the perirhinal cortex in the contralateral hemisphere; or (iii) bilaterally ablating first the amygdala, then adding fornix transection, then finally perirhinal cortex ablation. We found that both frontal/perirhinal and MDmc/perirhinal disconnection had a large effect on visual object recognition memory, whereas both amygdalectomy and the addition of fornix transection had only a mild effect. We conclude that the frontal lobe needs to interact with the perirhinal cortex within the same hemisphere for visual object recognition memory, but that routes through the amygdala and hippocampus are not of primary importance.
在术前对猴子进行视觉物体识别记忆训练。任务是在自动化设备中，对一系列试验中唯一随机生成的视觉刺激进行延迟样本匹配，刺激物是由随机生成的彩色形状构成的二维视觉物体。然后，我们研究了以下三种情况的影响：(i) 通过交叉单侧切除，将一侧半球的额叶皮质与对侧半球的嗅周皮质断开连接；(ii) 将一侧半球的背内侧丘脑核（MDmc）的大细胞部分与对侧半球的嗅周皮质断开连接；或(iii) 先双侧切除杏仁核，然后切断穹窿，最后切除嗅周皮质。我们发现，额叶/嗅周皮质和MDmc/嗅周皮质的断开连接对视觉物体识别记忆有很大影响，而杏仁核切除术和切断穹窿的影响较小。我们得出结论，额叶需要与同一半球内的嗅周皮质相互作用以进行视觉物体识别记忆，但通过杏仁核和海马体的通路并非至关重要。
