Chen Y Y, Chen P P, Xu L, Ernst P K, Wang L, Mills R P
Department of Ophthalmology, University of Washington, Seattle 98195-6485, USA.
J Glaucoma. 1998 Oct;7(5):312-6.
To assess the correlation between the results of peripapillary scanning laser polarimetry of the retinal nerve fiber layer (NFL) and automated visual field testing in patients with open-angle glaucoma.
Visual fields from 42 patients with varying stages of glaucoma were scored using Collaborative Initial Glaucoma Treatment Study (CIGTS) criteria. Mean deviation, pattern standard deviation, and CIGTS total and hemifield visual field scores were correlated with peripapillary NFL thickness measured by scanning laser polarimetry using summed, ratio-based, and modulation parameters.
Mean deviation and CIGTS total and upper hemifield score were significantly correlated with NFL retardation values using summed, ratio-based, or modulation parameters. The CIGTS lower hemifield score was significantly correlated with modulation parameter values only. Correlation of CIGTS scores was significantly stronger with modulation parameters than with summed parameters (total and lower hemifield scores) and ratio-based parameters (lower hemifield only) by the Hotelling t test.
Relative NFL thickness measured by scanning laser polarimetry correlates well with visual field defects seen on Humphrey perimetry of patients with open-angle glaucoma. Modulation parameters, in which the superior and inferior peak NFL thickness (as measured by scanning laser polarimetry) are adjusted for the patient's average minimum NFL thickness in the nasal and temporal quadrants, provided stronger correlation than summed parameters and ratio-based parameters.
评估开角型青光眼患者视网膜神经纤维层（NFL）的视乳头周围扫描激光偏振仪检查结果与自动视野检测结果之间的相关性。
采用协作初始青光眼治疗研究（CIGTS）标准对42例不同青光眼阶段患者的视野进行评分。平均偏差、模式标准偏差以及CIGTS全视野和半视野视野评分与通过扫描激光偏振仪测量的视乳头周围NFL厚度进行相关性分析，测量时使用总和参数、基于比率的参数以及调制参数。
使用总和参数、基于比率的参数或调制参数时，平均偏差以及CIGTS全视野和上半视野评分与NFL延迟值显著相关。CIGTS下半视野评分仅与调制参数值显著相关。通过Hotelling t检验，CIGTS评分与调制参数的相关性显著强于与总和参数（全视野和下半视野评分）以及基于比率的参数（仅下半视野）的相关性。
通过扫描激光偏振仪测量的相对NFL厚度与开角型青光眼患者 Humphrey视野计检测到的视野缺损相关性良好。调制参数在测量时会根据患者鼻侧和颞侧象限的平均最小NFL厚度对视乳头周围NFL厚度的峰值进行调整，与总和参数和基于比率的参数相比，其相关性更强。
