Kálmán J, Juhász A, Császár A, Kanka A, Rimanóczy A, Janka Z, Raskó I
Department of Neurology and Psychiatry, Albert Szent-Györgyi University Medical School, Szeged, Hungary.
Acta Neurol Scand. 1998 Sep;98(3):166-8. doi: 10.1111/j.1600-0404.1998.tb07288.x.
The regulatory role of apolipoprotein E in lipid transport and metabolism was utilized to investigate the allelic association between the apolipoprotein E4 (apoE4) allele and vascular dementia (VD) in a selected sample of Hungarian patients with multiple deep subcortical infarcts and leukoaraiosis.
Thirty-four Caucasian VD cases and 79 healthy control probands were involved in this study according to the criteria of ICD-10 and NINDS-AIREN International Workshop Diagnostic Criteria. The genomic DNA was isolated from whole blood and the apoE alleles were determined by polymerase chain reaction.
The E2, E3 and E4 allele frequencies in the VD group were 5%, 76%, and 19%, respectively; and significant (P<0.03) differences were found in comparison with the data on the healthy controls (E2, 6%; E3, 87%; E4, 8%). The apoE4 allele frequency was intermediate between HC and Alzheimer's dementia group (28%).
These results indicate that the apoE4 allele could be a risk factor not only for certain primary degenerative, but also for vascular dementias.
载脂蛋白E在脂质转运和代谢中的调节作用被用于研究匈牙利多发性深部皮质下梗死和脑白质疏松症患者样本中载脂蛋白E4（apoE4）等位基因与血管性痴呆（VD）之间的等位基因关联。
根据ICD - 10和NINDS - AIREN国际研讨会诊断标准，34例白种人VD病例和79例健康对照先证者参与了本研究。从全血中分离基因组DNA，并通过聚合酶链反应确定apoE等位基因。
VD组中E2、E3和E4等位基因频率分别为5%、76%和19%；与健康对照数据（E2，6%；E3，87%；E4，8%）相比，发现有显著（P<0.03）差异。apoE4等位基因频率介于健康对照和阿尔茨海默病痴呆组（28%）之间。
这些结果表明，apoE4等位基因不仅可能是某些原发性退行性疾病的危险因素，也是血管性痴呆的危险因素。
